Gene therapy for Morquio A disease successful in rat model
A novel gene therapy has fully corrected whole-body alterations in a rat model, paving the way for Morquio A therapies.
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Immune cells found co-operating to capture and “eat” bacteria
Researchers have identified a spider-like antibacterial mechanism by immune cells that could inspire Staphylococcus aureus treatments.
Scientists create cellular blueprint of multiple sclerosis lesions
An NIH team have built a cellular map of chronic multiple sclerosis (MS) lesions to identify cells that drive inflammation and potential therapies.
PP2A enzyme could be major driver of preeclampsia
A new study found that protein phosphatase 2 (PP2A) found to be a major driver of preeclampsia, potentially leading to treatments.
Novel tool can estimate number of T cells in cancer tumours
Researchers have developed a new method that can rapidly count the number of T cells in a tumour, helping to predict patient response to therapies.
New Gut Cell Atlas reveals genetic origins of Crohn’s disease
The Gut Cell Atlas comprises 428,000 cells in the gut and sheds light on the origin of Crohn’s disease and other intestinal diseases.
STING-activating drugs could customise cancer treatments
An imaging technique identified emerging drugs that activate the STING protein to alter metabolic pathway activity in cancer cells.
Artificial intelligence could revolutionise glycomics datasets
Researchers have created a tool that allows glycomics datasets to be analysed using artificial intelligence for early cancer diagnoses.
S1P may be a potential target for cerebral blood alterations
Sphingosine-1 phosphate was found to regulate blood glow in cerebral blood vessels in mice, presenting a potential therapeutic target.
Researchers simulate hepatitis B infection using computational method
The new study modelled the process of capsid disassembly of the hepatitis B virus at an atomic level to help develop targeted therapies.
Genomic study uncovers causes of lung cancer in non-smokers
An NIH study used whole genome sequencing to describe three molecular subtypes of lung cancer in non-smokers, possibly improving treatments.
Stem-like T cells could improve immunotherapy treatments
Targeting stem-like T cells within certain lymph nodes could improve the number of cancer patients that respond to immunotherapy treatments.
Researchers engineer “mini” CRISPR genome editing system
Stanford researchers have developed a multi-purpose “mini” CRISPR system, called CasMINI, that may be easier to deliver into human cells.
Scientists discover mechanism behind cardiac hypertrophy
New research has uncovered a mechanism underlying cardiac hypertrophy in mice, spurring novel avenues for potential treatments.
RN7SL1 RNA shown to activate T cells to fight against cancer
A new study found that the RNA RN7SL1 can activate T cells to seek out cancer cells, potentially improving cellular treatments.