Cartilage growth gene TRPV4 shows promise for joint repair therapy
The discovery that the TRPV4 gene regulates cartilage growth could lead to treatments for osteoarthritis and other cartilage diseases.
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Researchers identify potential drug to treat GIST tumours
A potential drug to treat a subset of gastrointestinal stroma tumours (GIST) have been found to tackle intestinal tract cancer.
Intranasal COVID-19 vaccine shown to be effective in animal models
A nasal spray of the COVID-19 Vaccine Oxford/AstraZeneca was found to protect hamsters and monkeys against SARS-CoV-2 in an NIH study.
Lung fibrosis in mice successfully reversed by scientists
A team of researchers have reversed lung fibrosis in a mouse model, highlighting a new therapeutic target for pulmonary fibrosis.
Signalling pathway identified as target against paediatric glioma
Researchers have found a vulnerability in a developmental signalling pathway, presenting a target for paediatric low-grade glioma formation.
Scientists develop novel strategy for tuberculosis vaccine
A research team have created a new strategy for developing an effective vaccine against a widespread form of tuberculosis.
New study may improve enzyme replacement therapy for Pompe patients
Researchers have developed a new method that could make enzyme replacement therapy more efficient for Pompe disease treatment.
High-intensity focused ultrasound therapy moves closer to the clinic
Researchers are investigating how high-intensity focused ultrasound (HIFU) can work on a cellular level to treat a range of cancers.
AI method reveals 17 existing drugs that may fight against COVID-19
Scientists used artificial intelligence to identify 17 existing drugs that could kill SARS-CoV-2 in cells, including a dietary supplement.
Multi-omics approach identifies genes associated with alcohol use disorder
First-of-its-kind study uses a multi-omics approach to provide a list of causal candidate genes associated with alcohol use disorder (AUD).
Scientists discover new clue for platelet activation to target thrombosis
Researchers have revealed a novel mechanism for platelet activation, suggesting a potential target for antithrombotic therapy.
Researchers identify novel genomic marker of childhood leukaemia
A team have found that two DNA changes appear to predict acute lymphoblastic leukaemia, illuminating genetic understanding of the disease.
New skin cell mechanism discovery could treat muscle-related diseases
Scientists have identified the mechanism behind the conversion of skin cells into immature muscle cells, which could lead to therapies preventing muscle degeneration.
Mechanisms behind synapse degeneration in Alzheimer’s unveiled
Researchers have uncovered a signalling pathway associated with glutamatergic synapse degeneration in the brains of mice with Alzheimer’s.
Researchers discover glycan “gateway” that enables COVID-19 infection
A supercomputing method has revealed details of glycan “gates” on the SARS-CoV-2 Spike protein that open to allow virus entry and infection.