Novel database could accelerate drug repurposing for various diseases
NICEdrug.ch is an open-access database that may help scientists assess potential drugs for a range of diseases more quickly.
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Mitochondria repair in mice may provide answers on Parkinson’s disease
Researchers used an experimental small molecule that helped restore the removal of damaged mitochondria from brain cells in a mouse model of Parkinson's.
Synthetic “switch” is a pivotal step for smart insulin therapy
A novel synthetic “switch” has been developed that could hold the key to revolutionary smart insulin therapy for diabetic patients.
Masitinib found to be an effective COVID-19 treatment in mouse model
Scientists from the University of Chicago discovered that the drug masitinib inhibits the replication of SARS-CoV-2 in mice.
Sunlight shown to trigger DNA mutation that causes melanoma
New research found mutations that cause melanoma result from a chemical conversion in DNA fuelled by sunlight, undermining previous theories.
Thalamus revealed as key area to target for certain brain disorders
Research shows that cells gather more data inside the thalamus than once believed, potentially changing medicines for brain disorders.
Enzyme found to be an “Achilles’ heel” in ovarian cancers
Scientists have uncovered the crucial role of the enzyme NMNAT-2 in ovarian cancers, as well as other biomarkers that could lead to treatments.
Genes behind antibiotic activity in bacteria uncovered by metabologenomics
Researchers have used comparative metabologenomics to uncover what may be “silencing” bacteria to produce desirable compounds.
Greasy hair proves to be an unexpected possibility for obesity treatment
Researchers have revealed that the immune system of obese mice treated with TSLP released lipids through sebaceous glands.
Removal of RNA-binding protein improves leukaemia survival
Study shows that removing the protein IGF2BP3 slows cancer growth and increases chances of survival of rare types of leukaemia in mice.
Novel insulin-producing implant to be created for type 1 diabetics
JDRF funds development of an insulin-producing implant to regulate blood glucose levels in type 1 diabetes patients.
Farnesol shows potential to prevent and treat Parkinson’s disease
Researchers have added to evidence that farnesol prevents and reverses brain damage linked to Parkinson’s disease in mouse models.
AKT degrader may become a new, effective treatment for many cancers
Researchers have discovered a therapeutic agent that is effective in vitro at disrupting a biological pathway that helps cancer survive.
Genetic treatment reverses age-related memory loss in mice
Scientists have shown that manipulating the perineuronal nets (PNNs) in the brains of mice led to the reversal of age-related memory loss.
“Untreatable” cases of cystic fibrosis may be undermined by new therapy
An experimental drug suggests that therapy for currently untreatable cases of cystic fibrosis is “clearly achievable”.