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Snapshots of a mouse brain show OPCs nibbling on neurons
A US researcher studied 3D structures of brain cells and connections, revealing new role for oligodendrocyte precursor cells (OPCs), in mice.
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Baylor College of Medicine
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ELRIG: New modalities in pharmacology and drug discovery
Drug Target Review’s Ria Kakkad recently visited ELRIG and the British Pharmacological Society’s conference on New Modalities in Pharmacology and Drug Discovery which took place in London, UK. This article shares some of the key takeaways from the event.
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Animal study shows abnormal activity of brain circuit causes anorexia
Researchers have found that genetically and pharmacologically restoring the normal activity of the brain circuit improved anorexia, opening the possibility of developing a treatment strategy for affected individuals in the future.
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Nose organoids reveals first stages of SARS-CoV-2 and respiratory syncytial virus infection
Using nose organoids, researchers have highlighted key differences between the infection by SARS-CoV-2 and that of respiratory syncytial virus.
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Bone marrow stem cell transfusions show promise as potential treatment for sepsis
New research has shown that one-time infusion of stem cells from bone marrow improves the survival of mice with sepsis.
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Novel technology could significantly advance genomics field
New technology system of drug-based markers for the selection or counter-selection of genes may advance genetic screening methods.
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New screening method identifies COVID-19 protein inhibitor
Researchers use fast and cost-effective technology to identify the viral protein inhibitor Mpro as a potential drug against COVID-19.
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Novel model developed to resemble aberrant IPF lung epithelium
A new model that closely resembles aged lung epithelium in idiopathic pulmonary fibrosis has been developed, possibly leading to treatments.
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NPSR1 gene discovered as a key cause of endometriosis
NPSR1 has been identified as a genetic cause of endometriosis, revealing a potential drug target that may lead to better therapies.
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Novel gene therapy for heart failure moves closer to clinic
New research by US institutions in pigs shows that knocking down a particular signalling pathway after heart failure renews heart tissue.
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Reference genome comparison finds exome variant discrepancies
Scientists have found differences in 206 genes between the GRCh38 (hg38) and GRCh37 (hg19) human reference genomes.
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Analysis of proteomic data reveals potential therapeutic targets for cancer
Researches have provided a proof-of-concept that proteomic analysis could be used to identify drivers of aggressive cancers.
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Researchers find MAPK4 enzyme presents target for prostate cancer
Research has shown that MAPK4 activates two molecules in cellular signalling pathways involved in prostate cancer growth.
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ES17 phages can destroy bacteria before gut infection in mice
A study has shown that the ES17 phage binds to heparan sulphate and can target and eliminate ExPEC bacteria in animal models.
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Drug target for spinocerebellar ataxia type 1 identified by researchers
A team has found that a mutation in the ATAXIN-1 gene causes spinocerebellar ataxia type 1 (SCA1), presenting a drug target for the condition.