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Key regulator of sperm maturation revealed as a target for male infertility treatments
Scientists demonstrated that NELL2, a factor release by the testis, is essential for sperm to mature into motile cells able to fertilise an egg.
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Baylor College of Medicine
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Using scientific literature to aid the development of a safe and effective COVID-19 vaccine
Researchers in the US describe how they utilised previously published scientific literature to guide the design of their potential COVID-19 vaccine.
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VP3 protein: revealing the structure of a potential rotavirus drug target
Researchers hope that by revealing the rotavirus VP3 protein structure and mRNA capping functions, novel antivirals could be designed to prevent or combat rotavirus infections.
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Alternative splicing regulators like AKAP8 prevent cancer metastasis
A study revealed that AKAP8 promotes the alternative splicing of proteins, preventing breast cancer metastasis in animal models and could be the target of future therapies.
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Antiviral treatments lead to development of a new kind of cancer drug
Drugs that were being developed to treat enterovirus have also been found to treat certain cancers in mice.
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Assay for reading six molecular pathways simultaneously developed
Researchers have developed a luciferase assay that can be used to monitor the effects of treatments on six different molecular targets at once.
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Activating bone stem cells has potential therapeutic applications
A study has demonstrated that activating bone periosteal stem cells leads to increased bone healing in mice, presenting a potential therapeutic strategy.
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Novel therapeutic strategy reverses autism symptoms in mice
Researchers have discovered a pathway that causes behavioural abnormalities and other hallmarks of autism; they also revealed how to silence this and reverse the symptoms in mice.
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Alzheimer’s disease linked to tau-mediated RNA splicing errors
A new study has shown the possibility of using RNA splicing as a potential molecular target for Alzheimer's disease.
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Immune cell function in cancer immunotherapy revealed
Researchers have discovered the roles that immune cells play in tumour growth and breast cancer immunotherapy which could aid in drug development.
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Study of TP53 mutations shows insight into the gene’s function
New study sheds light on how the TP53 gene becomes mutated and how those mutations can help predict clinical outlooks for cancer.
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Discovering new routes to cancer drug discovery with neutrons
From the world’s flagship neutron science facility, Institut Laue-Langevin (ILL), Matthew Blakeley shares insights into how they are harnessing the power of neutrons to aid their search for new cancer treatments.
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Colon cancer proteins and gene analysis uncovers potential new treatments
A new study analysing both the entire set of genes and all the proteins produced by colon cancer tissues has revealed a more comprehensive view of the tumour.
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Drug targets for Dengue, Zika and Ebola viruses
US researchers have identified possible drug targets for Dengue, Zika and Ebola viruses…
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Protein mTOR regulated by Src in cancer growth
Researchers at Baylor College of Medicine and Texas Children's Hospital have identified a connection between cancer proteins mTORC1 and Src...