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BellBrook Labs

Poster: Assays for DDX3, DDX5, DDX17, RIG-I, and MDA5

10 May 2024 | By BellBrook Labs

A panel of HTS assays was developed using the Transcreener platform to accelerate the development of selective helicase inhibitors.

whitepaper

Poster: Assays for PRMT5, MLL4, METTL3/14, & NSP14

7 May 2024 | By BellBrook Labs

AptaFluor SAH: A Homogenous, Universal Assay for Histone, RNA, & DNA Methyltransferases. Case Study for PRMT5, MLL4, METTL3/14, & NSP14

whitepaper

A Guide to Measuring Drug-Target Residence Times

7 February 2024 | By BellBrook Labs

This guide provides technical background on concepts and techniques for use of Transcreener biochemical assays to measure drug-target residence times.

whitepaper

Whitepaper: Targeting kinases in the innate immune response

24 January 2024 | By BellBrook Labs

The guide provides examples of how Transcreener allowed rapid assay development to enable screening for kinases in innate immune pathways.

article

A Guide to DNA Damage Response and Innate Immunity

10 January 2024 | By BellBrook Labs

In this guide, we provide an overview of the DDR and innate immune pathway and describe Transcreener Assays and Assay Systems for key targets.

article

Unique self-activating proteins for drug discovery

5 January 2024 | By Bishal Parajuli (BellBrook Labs), Dr David P Siderovski (BellBrook Labs), Dr Dustin E Bosch (BellBrook Labs), Joseph Mendez (BellBrook Labs)

Naegleria fowleri infections are rare but almost invariably fatal, with pathologic sequelae spawning its common label as ‘the brain-eating amoeba’. Researchers identified two unique proteins within N. fowleri – self-activating guanine nucleotide-hydrolysing proteins (G proteins) – that present novel targets for drug discovery. This article summarises their work to date,…

article

Drug Target Review Assays ebook 2023

29 March 2023 | By Drug Target Review

Download your FREE ebook on assays, featuring articles from experts who write about developments in screening and the importance of performing comprehensive multiplex spatial and temporal profiling of drugs in pre-clinical research.

whitepaper

Guide: Navigating hit prioritisation using biochemical assays

7 September 2020 | By BellBrook Labs

So you have performed your screen. What’s next? This guide is focused on how biochemical assays are used for characterising and prioritising compounds.

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BellBrook Labs

article

Expert view: Targeting the cGAS-STING pathway with a new Transcreener HTS assay

24 March 2020 | By BellBrook Labs

DNA in the cytoplasm is an indicator of microbial infection, serving as a danger signal and resulting in induction of an innate immune response via the cyclic GAMP synthase (cGAS)/STING (Stimulator of INterferon-sensitive Genes) pathway.

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