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Children's Hospital of Philadelphia (CHOP)

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FOXO1 improves survival and function of CAR T cells

12 April 2024 | By Drug Target Review

Evidence indicating that FOXO1 plays a unique role in promoting T cell longevity could result in more effective CAR T cell therapies.

news

New class of CAR T cells combat previously “untargetable” cancer drivers

4 November 2021 | By Anna Begley (Drug Target Review)

The peptide-centric chimeric antigen receptors killed neuroblastoma cells in mice and could potentially expand the pool of immunotherapeutic targets.

news

Prenatal editing halts progression of Hurler syndrome in pre-clinical model

14 July 2021 | By Anna Begley (Drug Target Review)

US researchers used an AAV9 vector to edit a single base mutation in a prenatal mouse model, halting progression of Hurler syndrome.

news

Biomarker for blood vessel damage found in children with SARS-CoV-2

9 December 2020 | By Victoria Rees (Drug Target Review)

Elevated levels of a biomarker related to blood vessel damage have been found in all children with SARS-CoV-2 infection.

Neuroblastoma cells: nuclei are stained in red, microfilaments are in green and blue.

news

Novel targeted treatment shows efficacy in treating high-risk solid tumours

25 August 2020 | By Hannah Balfour (Drug Target Review)

The prodrug developed by researchers caused long-term remission in all murine models of high-risk or drug-resistant cancers with fewer side-effects than a comparable drug.

news

Algorithm to predict sites of DNA methylation and drug targets developed

7 August 2020 | By Victoria Rees (Drug Target Review)

A machine learning algorithm that predicts sites of DNA methylation could aid in the identification of disease-causing mechanisms, say researchers.

coronavirus particle in the crosshares with 'target locked' written above

news

Computational approach identifies novel COVID-19 vaccine targets

9 June 2020 | By Hannah Balfour (Drug Target Review)

Researchers used computational tools to identify regions of the SARS-CoV-2 virus that could potentially provide a safe and long-term immune response.

news

Myc gene linked to alternative splicing changes in several cancers

18 February 2020 | By Mandy Parrett (Drug Target Review)

A collaboration of academic institutions in the United States has identified a gene that is linked to alternative splicing changes that occur in several cancers.

news

Schizophrenia gene regulator identified by study

11 September 2019 | By Victoria Rees (Drug Target Review)

Using both computational models and stem cell-based experiments, researchers have identified a gene regulator of schizophrenia.

news

Rare mechanism for ALL to relapse after CAR-T therapy

2 October 2018 | By Iqra Farooq (Drug Target Review)

A single leukemic cell has become resistant to CAR-T therapy after unknowingly engineered with the leukemia-targeting CAR lentivirus...

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Children's Hospital of Philadelphia (CHOP)