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Mini-colons offer improved cellular diversity, longevity and function
Mini-colons, which closely resemble in vivo tissue, were used for several applications, including the characterisation of anticancer drug toxicity profiles.
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Ecole Polytechnique Fédérale De Lausanne (EPFL)
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Mesothelial cells in omental adipose tissue hinder adipogenesis
The discovery that omental fat has a mechanism to limit adipocyte formation may lead to new treatments for obesity and metabolic disease.
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Diagnosing inflammatory diseases with synthetic peptides
Researchers from Switzerland identify peptides that detect and measure a key biomarker in inflammatory conditions.
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Targeting tau – chasing a treatment for Alzheimer’s
Alzheimer’s disease remains one of the largest challenges for the global ageing population. In this article, Victoria Rees, Editor of Drug Target Review, reviews some of the latest research, highlighting how progress has been made in understanding tau as well as how to potentially target this protein as a therapeutic strategy against…
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Scientists reveal ultrastructure of Huntington’s disease
Researchers used advanced microscopy and proteomics to unveil new findings on Huntington's disease and open avenues to future treatments.
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Novel database could accelerate drug repurposing for various diseases
NICEdrug.ch is an open-access database that may help scientists assess potential drugs for a range of diseases more quickly.
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Researchers identify promising drug target for Huntington’s disease
Researchers have found the TBK1 enzyme regulates the degradation and clearance of the huntingtin protein, making it a drug target for Huntington's disease.
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Researchers develop first synthetic inhibitor of coagulation factor XII
A new FXII inhibitor has been developed that efficiently blocked coagulation in a thrombosis model without increasing the risk of bleeding.
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Researchers use algorithm to design articifical proteins for vaccines
Scientists have developed a method for designing artificial proteins that tell the immune system which antibodies to produce so could enhance vaccine design.
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Novel antiviral material made from sugar developed by researchers
Modified sugar molecules have been developed by researchers as antiviral materials which are non-toxic to humans, according to a new study.
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Super-resolution microscopy builds multicolour 3D images from 2D
Researchers have developed a method of exploiting fluorescence in microscopy to generate 3D images of organelles and structures within cells from 2D images...
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New ligand binding site identified through computer simulations
Many therapeutic compounds target GPCRs and so new ligand binding sites can help to design drugs more efficient at targeting GPCR...
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Democratising clinical genomics while protecting data privacy
Sophia Genetics co-founder and CEO, Jurgi Camblong, tackles issues of privacy and security for healthcare patient data...
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Blocking LRH-1 causes liver cancer cells to starve
13 June 2016 | By Victoria White, Digital Content Producer
Scientists at EPFL have found a way to starve liver cancer cells by blocking a protein that is required for glutamine breakdown - LRH-1...
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Reprogramming corrupted immune cells to attack tumours
13 June 2016 | By Victoria White, Digital Content Producer
Researchers at EPFL have found a way to reclaim the corrupted immune cells, turn them into signals for the immune system to attack the tumour...