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New insights about the influence of STAP-1 on immune cell activation
The new findings could lead to a therapeutic target for immune-related disorders, like multiple sclerosis.
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Hokkaido University
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Augmenting cancer immunogenicity through MHC class I
A novel technology can reduce tumour sizes significantly and improve treatment efficacy when used with existing immunotherapy.
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Combination therapy effective against canine melanoma
A combination of radiotherapy followed by immunotherapy is a promising strategy for the treatment of oral malignant melanomas in dogs.
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Assessing the accuracy of model arteries
Japanese scientists have tested the material used to build models of arteries, revealing their suitability for use in medical education and surgical planning.
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Research shows lipid nanoparticles are highly effective in gene therapy
Lipid nanoparticles have been used to encapsulate CRISPR-Cas9 and deliver it to cells in mice, where it was highly effective at knocking down expression of a target protein.
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ASD-like symptoms in chicks caused by neonicotinoid
Japanese researchers found an ASD-like behavioural impairment in chicks, suggesting a molecular pathway of ASD pathogenesis.
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Key mechanism reveals how SARS-CoV-2 evades our immune system
Scientists have found that SARS-CoV-2 can knock out an important molecular pathway linked to an immune complex called MHC class I.
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Spike gene mutants could be used as novel COVID-19 vaccine
SARS-CoV-2 Spike gene mutants may be developed into immunogens for new vaccines against COVID-19, a study in hamsters has shown.
![Glioblastoma Multiforme (GBM) cells in culture [Credit: Dr Jin-Min Nam].](https://www.drugtargetreview.com/wp-content/uploads/glioblastoma-cells-750x500.jpg)
![Glioblastoma Multiforme (GBM) cells in culture [Credit: Dr Jin-Min Nam].](https://www.drugtargetreview.com/wp-content/uploads/glioblastoma-cells-e1601552379990.jpg)
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Identifying radioresistance drivers in glioblastoma multiforme
According to researchers, Rab27b and epiregulin contribute to the development of radioresistance and could be targeted to improve glioblastoma patient survival.
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Missing link found in rare inherited skin disease
Scientists are getting closer to understanding how a rare hereditary disease impairs the skin's barrier function, which determines how well the skin is protected.
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Neuronal link between chronic pain and depression discovered
The mechanism in the brain connecting chronic pain and depression could lead to treatments for both, according to researchers.
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Targeting mitochondria could reduce cancer invasiveness and resistance to radiotherapy
Uncovered details of a molecular pathway in cancer cells could lead to improved treatment...
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Obesity inhibits key cancer defence mechanism
Obesity could enhance cancer development while aspirin might prevent it - a new insight into potential targets for cancer prevention.
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New wrapping material enables high quality bioimaging
Scientists in Japan have developed a nano-sheet made of a fluorine-containing polymer and investigated its effectiveness in producing biological images...
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Researchers develop new system to detect spinal deformity
22 November 2016 | By Niamh Louise Marriott, Digital Content Producer
Hokkaido University researchers have developed a spinal symmetry-recognition system that can 3-dimensionally detect early stages of idiopathic scoliosis...