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Essential insights into HIV-1 latency mechanisms
HIV-Tocky, a new viral reporter system, uncovers the molecular mechanisms of provirus silencing and expression.
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Imperial College London
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New biological pathway in IBD discovered
Researchers have identified a new biological pathway driving IBD and similar conditions that could be targeted with MEK inhibitors.
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New method to label proteins could help track disease
Scientists have developed a new method to study the proteins released by cells, which could lead to the development of new tools to track diseases including cancer.
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Drug Target Review’s highlights from ELRIG Drug Discovery 2022
Victoria Rees and Ria Kakkad from Drug Target Review bring you the key takeaways from the ELRIG Drug Discovery 2022 event in London.
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Metal-based molecule could inhibit build-up of Alzheimer’s peptides
UK researchers have created a metal-based molecule that inhibits the build-up of Alzheimer’s-associated peptide, amyloid-β, in lab tests.
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AI platform developed to reveal how bacteria infect intestines
A new artificial intelligence (AI) method has been created to uncover which proteins enable bacteria to infect human intestines.
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Molecule in body that blocks antibody binding to SARS-CoV-2 discovered
Biliverdin attaches to a region of the SARS-CoV-2 Spike protein, stabilising it so that it is not able to expose its structure to antibodies, a new study has shown.
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Broad T-cell responses: designing a rhinovirus vaccine
The multiple serotypes of rhinovirus have presented difficulties for vaccine developers. Now, a team led by Professor Gary McLean from London Metropolitan University and Imperial College London, alongside Professor Sebastian Johnston from Imperial, has formulated a potential vaccine. Nikki Withers spoke to McLean to discover how the vaccine works and…
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UK Government to fund four studies investigating long COVID
The UK Government will give £18.5 million in funding to four studies researching the causes and potential treatments of long COVID.
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New probes shine a light on the role of four-stranded DNA in human cells
A better understanding of the role of four-stranded DNA (G-quadruplex) could enhance cancer therapeutics, said the developers of the probes.
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Developing drugs for disordered proteins
Scientists have developed a drug-like molecule to target amyloid-beta, a disordered protein implicated in Alzheimer's disease that has been considered undruggable.
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UK government funds 21 new research projects into COVID-19
A total of 21 COVID-19 research projects have been granted funding by the UK government, including vaccine and therapeutic development.
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Syndecan-4 cell sensory protrusions activate hallmarks of cancer
A study has revealed that activation of syndecan-4 sensory protrusions extending from cells may be a future target for cancer therapy.
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New way to target treatment-resistant cancers identified
A new mechanism by which cancer cells become resistant to chemotherapy has been found which could lead to a new target for drugs.
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Weapon bacteria could be copied to create new forms of antibiotics
New antibiotics could be designed by discovering the mechanism a weapon bacteria uses to vanquish their competitors.