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New 3D genomic profiling technique details PanINs
Researchers have developed a 3D approach to improve the characterisation of pancreatic intraepithelial neoplasias.
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Johns Hopkins Kimmel Cancer Center
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Reprogramming immune-suppressive macrophages in tumours
A novel drug, JHU083, turns into its active, glutamine-blocking form inside tumours, shrinking prostate and bladder cancers in mice.
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Combatting T-cell tumours with antibody drug conjugates
One treatment with the anti-TRBC1-SG3249 ADC combination saw cancer elimination within seven days in mouse models.
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Targeting Inc-HLX-2-7 shrinks group 3 medulloblastoma tumours
An intravenous treatment to block lnc-HLX-2-7 from binding to the HLX promoter shrunk medulloblastoma tumours, prolonging survival in mice.
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New algorithm identifies high-risk precancerous lesions
Researchers have developed an algorithm which could improve diagnostics of ovarian high-grade serous carcinoma.
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New developments in the research field of immuno-oncology
The exciting potential of immunotherapy for cancer treatment continues its exploration and here, Drug Target Review investigates three of the latest pre-clinical developments in immuno-oncology research.
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Novel cell reprogramming cocktail could advance regenerative medicine
Scientists have showed that a three inhibitors (3i) cocktail could reprogramme fibroblasts to a naïve embryonic stem cell-like state and remove disease-associated epigenetic changes.
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Protein vital for breast cancer metastasis discovered
A research team have identified a protein that binds breast cancer cells together, allowing them to metastasise, which could be significant in the development of cancer therapies.
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‘Inconsistent’ use of antibodies found in laboratory experiments
16 May 2019 | By
Researchers say they have affirmed inconsistencies in the use of a common laboratory procedure called immunohistochemical staining.
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Algorithm used to map cancer resistance to drugs
New methods of studying the evolution of treatment resistance in head and neck cancer are being developed by researchers at the Johns Hopkins Kimmel Cancer Center...
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Five genetic changes linked to pancreatic cancer risk
Researchers have discovered changes to five new regions in the human genome that may increase the risk of pancreatic cancer...
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Single blood test screens for eight cancer types
Researchers have developed a single blood test that screens for eight common cancer types and helps identify the location of cancer...