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Determining the cellular architecture of multiple sclerosis lesions
Using in situ sequencing, a collaborative research group analysed 260 genes and discovered new sub-structures in MS lesions.
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Karolinska Institutet
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Nasal administration of IgA antibodies protects from SARS-CoV-2
Genetic engineering created IgA antibodies that bind to the SARS-CoV-2 spike protein in a similar way to IgG antibodies.
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Metabolic change in hippocampus indicates Alzheimer’s disease
Using RNA sequencing, scientists find that metabolic increase in the brain is an early indicator of Alzheimer's disease.
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Harnessing machine learning for early cancer detection in primary care
Machine learning (ML) presents a promising opportunity to revolutionize early cancer detection in primary care, addressing the challenges associated with diagnostic errors and improving patient outcomes. The potential of ML in this field is highlighted in a recent paper published in Oncoscience
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New immunotherapy approach holds promise for ovarian cancer
A new approach using CAR T-cell therapy is suggested by Swedish researchers as an effective treatment for ovarian cancer.
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New database maps proteins that could predict cancer
Swedish researchers unveiled a new cancer protein profile database compiled from artificial intelligence and machine learning.
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Drug Target Review’s top content picks from 2022
In this article, Drug Target Review’s Izzy Wood and Ria Kakkad share some of the most ground-breaking moments from drug discovery this year.
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Immune cells in ALS patients: predicting disease progression
Swedish researchers have discovered that by measuring immune cells in the cerebrospinal fluid when diagnosing ALS, it is possible to predict how fast the disease may progress.
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Targeting tau – chasing a treatment for Alzheimer’s
Alzheimer’s disease remains one of the largest challenges for the global ageing population. In this article, Victoria Rees, Editor of Drug Target Review, reviews some of the latest research, highlighting how progress has been made in understanding tau as well as how to potentially target this protein as a therapeutic strategy against…
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3D imaging helps to better understand the early stages of Alzheimer’s disease
Researchers have successfully characterised a part of the brain that shows the earliest accumulation of tau protein, an important biomarker for the development of Alzheimer's disease.
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New generation of COVID-19 vaccines show promising results
Researchers have designed a COVID-19 vaccine to be less sensitive to mutations and equipped for future strains.
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Researchers have linked resistance to kidney cancer treatment to low mitochondrial content in cancer cells
When the researchers increased the mitochondrial content with an inhibitor, the cancer cells responded to the treatment.
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Target protein for diabetes drug linked to reduce the risk of Alzheimer’s disease
Scientists from Karolinska Institutet have found mechanisms associated with a particular diabetes drug that can also help to protect against Alzheimer’s disease.
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How RNA molecules can control repair of human DNA in cancer cells revealed
New research from the Karolinska Institutet shows that RNA molecules have a much broader function in the development of cancer.
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Memory T cells respond to SARS-CoV-2 Omicron variant, study shows
Research has shown that memory T cells formed following SARS-CoV-2 infection or mRNA vaccination respond to the Omicron variant.