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Lewis Katz School of Medicine at Temple University

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Chances of eliminating HIV infection increased by dual gene-editing method

4 May 2023 | By Izzy Wood (Drug Target Review)

US researchers suggest that combing a dual gene-editing approach with antiretroviral drugs can eliminate HIV infections in animal models.

human digestive system anatomy 3d illustration

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Study reveals cellular diversity of oesophageal tissue

27 April 2022 | By Ria Kakkad (Drug Target Review)

Researchers defined 11 subsets of cells found in the oesophagus of mice. These findings could potentially help clinicians diagnose or treat certain types of cancer.

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Positive pre-clinical results for CRISPR-based HIV therapy

23 November 2021 | By Anna Begley (Drug Target Review)

The CRISPR-based therapy called EBT-101 excised HIV proviral DNA from the genomes of different cells and tissues in human cells and mice.

shape of a human brain constructed out of red coronavirus particles

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SARS-CoV-2 can disrupt the blood-brain barrier, find scientists

2 November 2020 | By Hannah Balfour (Drug Target Review)

Binding of SARS-CoV-2 spike proteins to the brain’s endothelial cells can cause the blood-brain barrier to become leaky, potentially causing the neurological symptoms associated with COVID-19.

Pharmacological chaperone therapy shown to prevent Alzheimer's in mice

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Pharmacological chaperone therapy shown to prevent Alzheimer’s in mice

22 January 2020 | By Rachael Harper (Drug Target Review)

A new study is the first to describe a novel pharmacological chaperone that is capable of preventing Alzheimer's disease in mice.

news

Research reveals calcium signalling pathway in T cells

9 October 2019 | By Victoria Rees (Drug Target Review)

A study has uncovered the mechanism behind calcium entry and exit into T cells, which could be used in development of autoimmune disease treatments.

news

New target for regulating mitochondria during stress identified

19 September 2019 | By Rachael Harper (Drug Target Review)

A new target has been identified for the treatment of heart failure, heart attack, stroke and neurodegeneration.

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Scientists identify promising new target to combat Alzheimer’s disease

4 September 2019 | By Rachael Harper (Drug Target Review)

New research is the first to link maladaptive changes in calcium transport by mitochondria to the progression of Alzheimer's disease.

news

Tauopathy-regulating protein identified

11 July 2019 | By Victoria Rees (Drug Target Review)

Researchers have discovered that the VPS35 molecule can be utilised in preventing neurodegenerative disorders.

news

Potential cure for HIV revealed through combined therapies

3 July 2019 | By Victoria Rees (Drug Target Review)

A new study has used combined therapies to eliminate HIV from mice models, providing potential future cures.

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Lewis Katz School of Medicine at Temple University