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Specific HERV expression signatures linked to MS and ALS
The study identified which specific HERVs are important in increasing susceptibility for neurodegenerative diseases.
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National Institutes of Health (NIH)
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mRNA vaccine provides enhanced protection against mpox
The mRNA vaccine candidate more effectively limited symptoms and disease duration in non-human primates.
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Investigating CWD transmission with human cerebral organoid models
Following direct exposure of human CNS tissues to CWD prions, a significant resistance to the propagation of infection was found.
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Novel tool to rapidly diagnose sarcoidosis
A highly specific blood test can differentiate between patients with sarcoidosis and other respiratory conditions, like TB or lung cancer.
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Substance abuse inhibits cognitive flexibility
New US research underlines the relationship between substance use and significant modifications to an inhibitory brain circuit, resulting in decreased cognitive flexibility
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T cells’ vital role in boosting immune responses
In this article, Drug Target Review's Izzy Wood uncovers the cutting-edge breakthroughs in T cell research that are revolutionising our understanding of the immune system and paving the way for new therapies and treatments.
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The genetic modifier approach: identifying the right target for rare diseases
In this article, Dr Vincent Blomen, Senior Director of Target Discovery at Scenic Biotech, takes us through the realm of rare diseases. In the case of most of these diseases, a singular genetic anomaly often reigns supreme, yet its impact on patients can be vastly divergent. Enter modifier genes, the…
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Genomic sequencing helps find treatment for rare genetic skin disorder
US researchers use genome sequencing to reveal genetic basis for disabling pansclerotic morphea, a severe inflammatory disease.
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New approach to treating liver cancer
Results from a US study in cells and mice may have implications for the development of a new class of anticancer drugs against liver cancer.
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Blocking host proteins: an improved COVID-19 treatment approach?
Scientists report news of a promising new compound that effectively blocks the activity of proteins on cells that are necessary for SARS-CoV-2 to cause infection.
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New molecule could complement antibiotics to treat pneumonia
Scientists targeted a mouse's own cells using a synthetic molecule called EEZE, presenting a novel way to treat pneumonia.
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Scientists explore CA2 neuron mitochondria for memory loss targets
The team will receive $2 million over five years to investigate the CA2 brain region for the development of neurological therapies.
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$7.5 million to fund senescent cell research for age-related disease
Washington University will receive $7.5 million from the NIH to study senescent cells for treatments against age-related diseases.
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NINDS awards Sinopia $3.3m for development of Parkinson’s drug candidate
Sinopia has been awarded a $3.3 million Fast-Track SBIR grant to fund the study for its small molecule candidate for Parkinson’s disease.
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Scientists create cellular blueprint of multiple sclerosis lesions
An NIH team have built a cellular map of chronic multiple sclerosis (MS) lesions to identify cells that drive inflammation and potential therapies.