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AI can predict which research will translate to clinical trials
Researchers have created an AI model that analyses the citations of studies, predicting their potential for eventual clinical application.
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National Institutes of Health (NIH)
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AI-driven automated chemistry as a tool to accelerate drug discovery
Typically, early drug discovery campaigns start with the screening of chemical libraries to identify candidate chemotypes modulating a particular target and/or phenotype. Success of the primary screening depends on multiple factors related to both biology and chemistry. These include the target’s druggability, sensitivity and specificity of assay system, composition and…
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High-throughput platform could map cancer drug target activity
Manchester University researchers have developed a high-throughput platform to analyse and study a family of enzymes that are linked to cancer...
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Could gene mutation offer new treatment options for cardiometabolic disease?
Researchers in the states have discovered a particular gene mutation that slows down sugar metabolism in the gut, indicating future treatment options for individuals with cardiometabolic and sugar-associated diseases.
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Novel drug therapy partially restores hearing in mice
A small-molecule drug is one of the first to preserve hearing in a mouse model of an inherited form of progressive human deafness, report investigators at the University of Iowa, Iowa City, and the National Institutes of Health’s National Institute on Deafness and Other Communication Disorders (NIDCD).
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NIH-funded study finds new evidence that viruses may play a role in Alzheimer’s disease
Analysis of large data sets from post-mortem brain samples of people with and without Alzheimer's disease has revealed new evidence that viral species, particularly herpesviruses, may have a role in Alzheimer’s disease biology.
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Scientists uncover steps to kinase enzyme activation
A new study by the University of Arizona (UA) suggests that revealing all the steps required to activate an enzyme called a protein kinase may help identify new ways to target cancer.
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NIH funds three national cryo-EM service centres and training for new microscopists
The NIH is supporting efforts to broaden biomedical scientists’ access to cryo-electron microscopy the imaging method that is revolutionising structural biology...
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ALS researchers begin recreating human spinal cords on a chip
NIH-funded study closes in on personalised drug testing for neurological disorders...
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Tempol provides a potential treatment for Chuvash polycythemia
A study in mice suggests that experimental drug may be effective against mountain sickness and other polycythemias...
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Autoimmune disease research community gets boost from AMP RA/SLE study results
Data from the Phase I study of collaborative industry partnership AMP are now available, meaning scientists can benefit from access to important research about Rheumatoid Arthritis and Systemic Lupus Erythematosus.
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New study directly links mossy brain cell activity to epilepsy symptoms
New findings from an NIH-funded study of mice suggest that loss of mossy cells may contribute to seizures and memory problems in a form of epilepsy.
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RT-QuIC assay adapted to test for Parkinson’s and dementia with Lewy bodies
NIH scientists have modified an assay to offer the possibility of improving early diagnosis of Parkinson’s disease and dementia with Lewy bodies...
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Nicotinamide riboside shows cognitive benefits in Alzheimer’s disease
A form of vitamin B3 has been found to prevent neurological damage and improve cognitive and physical function in a new mouse model of Alzheimer’s disease...
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Scientists uncover the secret to how piRNAs defend the genome
Researchers from the University of Chicago have uncovered the mechanism by which small RNA molecules (piRNAs) locate and silence foreign invading genes, whilst avoiding ‘self’ genes.