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NIH study identifies new targets for anti-malaria drugs
Researchers have sought to uncover the role of plasmepsins IX and X, produced by P. falciparum for metabolic processes...
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National Institutes of Health (NIH)
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Three-in-one antibody may protect from HIV-like virus
A three-pronged antibody has been found to protect from infection with two strains of SHIV, better than individual natural antibodies...
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Flow cytometry – accelerating neuroscience research
Flow cytometry continues to evolve at a fast pace and provides neuroscientists with the ability to perform many highly-specialised assays simultaneously. It meets the demands of cutting-edge research in neuroscience that has allowed researchers to isolate particular neural cells from heterogeneous population and catalogue its molecular or physical features...
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NGS: empowering infectious disease research beyond reality
Pushpanathan Muthuirulan & Pooja Sharma explain how high-throughput next-generation sequencing (NGS) technologies are revolutionising our ability to characterise infectious diseases at genomic, transcriptomic and epigenetic levels...
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Sequencing all 24 human chromosomes uncovers rare disorders
Study from NIH may help improve prenatal genetic screening...
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Bacterial antibiotic resistance pathways identified
Researchers have described two structures and mechanisms - efflux pumps and reinforced cell walls - that certain disease-causing bacteria use to keep antibiotics away...
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US Phase 2 trial to test targeted drugs in paediatric tumours
Phase 2 trial to explore targeted therapies for children with solid tumours that harbour specific genetic mutations which have progressed during or after standard therapy...
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Researchers use smartphone data in global study of physical activity
Researchers at Stanford University in Palo Alto, California, have tracked physical activity by population for more than 100 countries.
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Study asks if mistaken antibodies led research down 20-year dead end
For nearly two decades researchers have sought a way to target an oestrogen receptor in the hope they could improve breast cancer survival, but an article contends that the effort may never pan out.
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Scientists identify single-gene mutations that lead to eczema
NIH-supported research suggests potential treatment strategy following the identification of single-gene mutations that lead to eczema.
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Plant-Mediated Modulation of Reactive Oxygen Species (ROS) Homeostasis
A review of Keap1/Nrf2 modulation of ROS homeostasis, and its pivotal role in the pathogenesis of cancer, Type 2 diabetes mellitus & neurological disorders.
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Researchers identify a key controller of biological machinery in cell’s ‘antenna’
St. Jude Children’s Research Hospital discovery of a regulatory enzyme working at the primary cilium could lead to treatments for the brain tumour medulloblastoma.
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Scientists jump hurdle in HIV vaccine design
Scientists at The Scripps Research Institute (TSRI) have made another important advance in HIV vaccine design.
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Researchers find key molecule that could lead to new anaemia therapies
Researchers find key molecule that could lead to new therapies for anaemia and other iron disorders.
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Scientists light the way for immune system to attack cancer
The science behind harnessing the immune system to fight cancer is complicated, but a University of Rochester Medical Center laboratory discovered a simple, practical way to use light and optics to steer killer immune cells toward tumours.