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Potential target for reducing obesity-related inflammation
16 November 2015 | By Victoria White
Investigators found that a protein called SIRT3 provides resistance to obesity-related inflammatory response...
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National Institutes of Health (NIH)
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Cholesterol-lowering vaccine shows promise in preclinical studies
10 November 2015 | By Victoria White
Scientists from the University of New Mexico and NIH have created a cholesterol-lowering vaccine that leads to reductions in LDL cholesterol in mice and macaques...
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Gene therapy shows promise in retinitis pigmentosa
14 October 2015 | By Victoria White
Research has shown that gene therapy preserved vision in a study involving dogs with naturally occurring, late-stage retinitis pigmentosa...
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Gene therapy shows success in vision loss mitochondrial disease
6 October 2015 | By Victoria White
Researchers have found that they can use gene therapy to improve visual in mice models for the vision disorder Leber hereditary optic neuropathy (LHON)...
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Enzymes: Ubiquitin-specific proteases as druggable targets
In much the same way that kinases and phosphatases attach and remove phosphate groups from proteins to modulate their activity, there are a series of enzymes (E1, E2, E3) that add one or more ubiquitins onto a protein, as well as enzymes that remove them (deubiquitinases; DUBs), thereby regulating their…
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MERS-CoV vaccine successfully tested in monkeys and camels
20 August 2015 | By Victoria White
Scientists have reported that an experimental vaccine given six weeks before exposure to MERS-CoV fully protects rhesus macaques from disease...
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Cells regenerate liver without cancer risk
17 August 2015 | By Victoria White
Researchers supported by the NIH have discovered a type of cell, known as hybrid hepatocytes, essential to regeneration of the liver...
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Experimental MERS vaccine shows promise in animal studies
29 July 2015 | By Victoria White
A two-step regimen of experimental vaccines against Middle East respiratory syndrome (MERS) prompted immune responses in mice and rhesus macaques...
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Protein RGS2 helps prepare for healthy egg-sperm union
27 July 2015 | By Victoria White
Researchers have discovered RGS2, a protein being looked at as a target for hypertension and heart ailments, plays a vital role in healthy egg-sperm union...
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Virus-like particle vaccine protects mice from influenza strains
22 July 2015 | By Victoria White
NIAID researchers have devised a way to induce protective immunity in mice against a wide array of influenza viruses using a VLP vaccine...
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Cholesterol metabolism in immune cells linked to HIV progression
20 July 2015 | By Victoria White
Lower levels of cholesterol in certain immune cells may help explain why some HIV-infected people are able to naturally control disease progression...
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Achaogen awarded $4.5 million contract to advance LpxC inhibitors
16 July 2015 | By Victoria White
Achaogen has been awarded a $4.5 million contract for the discovery and development of LpxC inhibitors for the treatment of bacterial infections...
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Research points to microglia as potential therapeutic target in retinitis pigmentosa
2 July 2015 | By Victoria White
A new study shows that microglia accelerate damage wrought by blinding eye disorders, such as retinitis pigmentosa...
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New “map” of TTLL7 protein helps researchers understand cellular transport
12 May 2015 | By
Scientists from TSRI and NIH have mapped out the structure of an important protein involved in cellular function and nervous system development - TTLL7...
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Anton Simeonov
6 February 2014 | By
Acting Branch Chief and Group Leader, National Institutes of Health