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Blastoids enable greater understanding of human gastrulation
Stem-cell based blastocyst models have enabled scientists to redefine the molecular signature and timing of the onset of gastrulation.
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Rockefeller University
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New scientist at Rockefeller University plans to unlock vast chemical spaces for drug discovery using algorithms
Jiankun Lyu hopes to use algorithms to find improved drugs by screening chemicals that may look different to a protein’s known ligands but work in a similar way.
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Novel screening reveals drug candidates for Huntington’s disease
Researchers have developed a new method that enables high-throughput screening of Huntington’s disease organoids.
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Small molecule RGX-202 prevents metastasis in colorectal cancer
RGX-202 was found to foil a key pathway that cancer cells rely on for energy in mice, presenting a possible new colorectal cancer therapy.
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Two-week-old human embryos reveal origin of Huntington’s disease
Scientists have discovered a signalling pathway alteration in embryos with Huntington’s disease, paving the way for ground-breaking treatments.
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The other end of the antibody: Fc biology and immunotherapy
Dr Björn Frendeus outlines how the growing biology surrounding the inhibitory Fc receptor FcγRIIb defines a target for improving existing and future antibody treatments.
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LY6E identified as potential immunoprotein against SARS-CoV-2
A study has demonstrated that the LY6E protein inhibits SARS-CoV-2 infection in human cell cultures, so a drug mimicking it could be a therapy for COVID-19.
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Researchers discover how gut infections may produce chronic symptoms
A new study into why neurons in the gut die and how the immune system protects them could lead to better treatments for IBS that work by boosting polyamine production.
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New technology developed to screen for Huntington’s treatments
Researchers have created a new technology which enabled them to discover more about the causes of Huntington’s disease and which can be used to test drugs.
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Study reveals new opportunity for gastrointestinal drug design
A study has shown that the organisation of the gut is broken into functional compartments, improving opportunities for gastrointestinal disorder drugs and oral vaccines.
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Uncovering the early origins of Huntington’s disease using CRISPR engineered embryonic stem cells
Researchers have developed a system to model Huntington's in human embryonic stem cells...
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Alzheimer’s Tau protein forms toxic complexes with cell membranes
Researchers identify the sequence and structural factors that drive Tau interaction with membranes...
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Potential new treatment for Fragile X targets one gene to affect many
Inhibitors of chromatin remodelling proteins may be a potential treatment for Fragile X Syndrome...
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Elimination of specific neurons outside the brain by new technique triggers obesity
A research team from Instituto Gulbenkian de Ciencia (IGC, Portugal), developed a new genetic technique that allows the elimination of specific neurons of the peripheral nervous system without affecting the brain.