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Texas Children's Hospital

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Slc4a4 restores normal brain function after ischemic stroke

20 May 2024 | By Drug Target Review

Researchers have elucidated how Slc4a4 governs astrocyte-endothelial cell interaction in blood-brain barrier maintenance and repair.

news

Investigating the inflammatory myocardial microenvironment

13 February 2024 | By Drug Target Review

By studying the molecular cell states within transplanted paediatric hearts, researchers have unlocked new treatment strategies.

news

A new way to visualise sensory neurons

19 June 2023 | By Izzy Wood (Drug Target Review)

US researchers have uncovered a novel method using a tool used to visualise ion channels in mechanosensory neurons.

news

Drug target for spinocerebellar ataxia type 1 identified by researchers

10 August 2020 | By Victoria Rees (Drug Target Review)

A team has found that a mutation in the ATAXIN-1 gene causes spinocerebellar ataxia type 1 (SCA1), presenting a drug target for the condition.

article

Using scientific literature to aid the development of a safe and effective COVID-19 vaccine

2 June 2020 | By Victoria Rees (Drug Target Review)

Researchers in the US describe how they utilised previously published scientific literature to guide the design of their potential COVID-19 vaccine.

news

Alzheimer’s disease linked to tau-mediated RNA splicing errors

9 October 2019 | By Rachael Harper (Drug Target Review)

A new study has shown the possibility of using RNA splicing as a potential molecular target for Alzheimer's disease.

news

HER2-targeted CAR T-cell therapy shows promise in patients with sarcoma

8 April 2019 | By Nic Losardo (Drug Target Review)

A combination of chemotherapy and chimeric antigen receptor (CAR) T cells designed to target the protein HER2 was found to be safe and showed clinical responses in paediatric and adult patients with advanced HER2-positive sarcoma...

news

Protein mTOR regulated by Src in cancer growth

19 October 2018 | By Drug Target Review

Researchers at Baylor College of Medicine and Texas Children's Hospital have identified a connection between cancer proteins mTORC1 and Src...

New evidence sheds light on how Parkinson’s disease may happen

news

New evidence sheds light on how Parkinson’s disease may happen

18 June 2018 | By Drug Target Review

Researchers at Baylor College of Medicine and Texas Children’s Hospital have identified unexpected new key players in the development of an early onset form of Parkinson’s disease called Parkinsonism.

news

OTUD7A gene identified as key player in 15q13.3 microdeletion syndrome

5 February 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers have identified in a mouse model OTUD7A as the gene that accounts for many characteristics of 15q13.3 microdeletion syndrome...

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