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BCL2 protein linked to metastatic castration-resistant prostate cancer
ICR researchers have discovered that prostate cancer patients with high BCL2 levels have a shorter overall survival rate.
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The Institute of Cancer Research (ICR)
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APOBEC3B genetic mutation signatures could be used to target cancers
An innovative new vaccine technique, which sensitises the immune system to the genetic signature of APOBEC mutations (often found in cancers), increases the efficacy of immunotherapies.
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Researchers must not rely on generic online searches for chemical probes, study finds
The ICR has revealed that during drug discovery, researchers should not use general search engines and vendor catalogue information to decide on their use of chemical probes.
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‘Liquid biopsy’ blood test spots new breast cancer subtype
2 September 2016 | By Niamh Louise Marriott, Digital Content Producer
The blood test detects mutations to a gene called oestrogen receptor 1, or ESR1, which indicate that receptors for the female hormone oestrogen in the cancer cells, which are usually driven by the hormone, have evolved to stay permanently switched on without it – meaning hormonal treatments that block oestrogen…
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Hsp90 inhibitors could treat lethal resistant prostate cancers
1 May 2016 | By Victoria White, Digital Content Producer
Researchers found that Hsp90 inhibitors target and inactivate a mechanism commonly used by prostate cancer cells to evade the effects of standard treatment...
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Cancer cells ‘persuade’ healthy cells to help disease grow
14 April 2016 | By Victoria White, Digital Content Producer
Cancer cells use a mutant gene to coerce neighbouring healthy tissue into helping with the disease’s growth and spread, a major new study reports...
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Cancers can resist treatment by ‘stealing’ blood vessels
8 April 2016 | By Victoria White, Digital Content Producer
A new study is the first to show that tumours can become resistant to drugs over time by learning to steal normal blood vessels from surrounding tissue...
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Children with cancer to be offered gene testing in personalised treatment initiative
31 March 2016 | By Victoria White
Children with cancer will be offered testing for genetic mutations in their tumours as part of an initiative to personalise children’s cancer treatment...
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canSAR: a portal to Big Data for drug discovery
9 February 2016 | By Dr Bissan Al-Lazikani and Elizabeth Coker, The Institute of Cancer Research, London
Dr Bissan Al-Lazikani and Elizabeth Coker discuss canSAR: the first public domain example of Big Data for drug discovery...
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London Cancer Hub to accelerate the discovery of treatments
3 February 2016 | By Victoria White
A new ‘roadmap’ document published today outlines how The London Cancer Hub will become a world-leading life-science campus...
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New study finds laws of nature predict cancer evolution
19 January 2016 | By Victoria White
Researchers believe that in the future, they could predict how a cancer will grow and develop by applying natural laws to single genetic snapshots taken from a cancer...
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CanSAR cancer drug discovery database goes 3D
4 January 2016 | By Victoria White
The updated canSAR database will allow scientists working in the UK and across the globe to design new cancer treatments more effectively...
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ICR identify Brf2 as a potential target for future cancer drugs
4 December 2015 | By Victoria White
ICR scientists have discovered Brf2 acts as a ‘master switch’ within cancer cells that seems to override the normal stress response...
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Chemical probe switches off two cancer-causing proteins
26 October 2015 | By Victoria White
The discovery sheds new light on the role these proteins play in driving cancer cell proliferation...
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Testicular cancer found to be ‘strongly heritable’
9 September 2015 | By Victoria White
New research suggests genetic inheritance is much more important in testicular cancer than in most other cancer types, where genetics typically accounts for less than 20% of risk...