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Mapped protein structure of Hepatitis C could lead to vaccine
Scripps scientists have mapped the protein structure of the Hepatitis C virus, paving the way for an effective vaccine.
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The Scripps Research Institute
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New drug has potential to turn COVID-19 virus against itself
The Scripps Research team showed that a variation of an already FDA-approved therapeutic for neurological disease can block COVID-19 infection in animals.
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In search of COVID-19 antibodies
Antibody therapy has been a critical part of the COVID-19 research campaign to treat severe cases. Unfortunately, despite many promising candidates, scientists have yet to find one that passes clinical trials. This article by Drug Target Review’s Ria Kakkad highlights some of the most recent developments in the search for COVID-19…
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New findings could lead to a vaccine that can offer protection against emerging COVID-19 variants
Scientists have discovered antibodies that are effective against many different COVID-19 variants.
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Immune protein may contribute to alcoholism relapse
Scientists have found that an immune protein, CSF1, may cause anxiety during alcohol withdrawal, therefore causing relapse.
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Scientists target ALS and dementia RNA using novel molecule
The small molecule successfully targeted the C9orf72 gene that causes amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
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Small molecule to potentially treat diabetes discovered in screening study
A small molecule found in a cell-based ultra-high-throughput screening campaign was shown to treat diabetes in cells and mice.
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Screening identifies existing drugs as potential COVID-19 therapies
Scientists have found four clinically approved drugs and nine compounds with the potential to be repurposed as therapeutics for COVID-19.
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Cross-reactive antibody could form basis of broad coronavirus vaccine
Researchers have discovered a cross-reactive coronavirus antibody that could aid in the development of a broad-acting vaccine or treatment.
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Most antibodies targeting SARS-CoV-2 use specific immunoglobulin subtype
Researchers reveal IgHV3-53 is the most common immunoglobulin mutation used to target the receptor binding domain on the SARS-CoV-2 spike protein.
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Researchers reveal how a key human anti-HIV antibody prevents infection
The team used cryogenic electron microscopy (cryo-EM) to show how the 10E8 antibody interacts with the HIV’s fusion protein to neutralise the virus.
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Study finds coronaviruses do not readily induce cross-protective antibody responses
Researchers have found that antibodies produced in response to SARS and COVID-19 are cross-reactive, but not cross protective in cells and mice.
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Researchers to screen compound library for antiviral drugs to combat COVID-19
Scripps Research has announced it will screen over 14,000 compounds to see if any present significant activity against COVID-19, for use in a therapeutic.
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New screening method identifies potential compounds to combat cancer
The new screening technique may enable development of novel combination-immunotherapy regimens against cancers and persistent infections.
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Hidden influenza vulnerability found in human antibodies
Scientists have discovered an unexpected weakness in the influenza virus protein.