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Modelling the blood-brain barrier with organoids

22 May 2024 | By Drug Target Review

The world’s first generation of human BBB organoids from hPSCs accurately replicated features of cerebral cavernous malformation.

Woman Wearing Brainwave Scanning Headset Sits in a Chair In the Modern Brain Study Laboratory/ Neurological Research Center. Monitors Show EEG Reading and Brain Model.

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Scientists discover anti-inflammatory molecules SGDGs decline in the ageing brain

1 November 2022 | By Ria Kakkad (Drug Target Review)

The molecules, called SGDGs, may lead to new ways to treat age-related neurological diseases.

Hand holding uterus shape made from paper on pink background.

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New combinatorial strategies to treat ovarian cancer

20 April 2022 | By Ria Kakkad (Drug Target Review)

Researchers have found how ovarian cancer tumours defy immunotherapy, identifying new molecular targets that might boost immune response.

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New drug target identified for myelodysplastic syndrome

8 October 2021 | By Anna Begley (Drug Target Review)

Researchers have uncovered how mutations affecting RNA splicing alter cells to develop myelodysplastic syndrome (MDS).

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Zaki syndrome: the newly uncovered condition and its potential cure

1 October 2021 | By Anna Begley (Drug Target Review)

Dubbed 'Zaki syndrome', the condition affects prenatal development of several organs and was identified using whole genome sequencing.

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Artificial intelligence could revolutionise glycomics datasets

9 September 2021 | By Anna Begley (Drug Target Review)

Researchers have created a tool that allows glycomics datasets to be analysed using artificial intelligence for early cancer diagnoses.

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Controlling HSP27 “switch” could be key to sepsis therapeutics

1 September 2021 | By Anna Begley (Drug Target Review)

Study reveals that the HSP27 protein plays a role in regulating blood vessel leakage, providing new targets for drugs against sepsis.

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Neutrophil nanosponges soak up rheumatoid arthritis promoting proteins

3 September 2018 | By Iqra Farooq (Drug Target Review)

The neutrophil nanosponges can absorb and neutralise cytokines which play a role in the development of rheumatoid arthritis...

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Blood test rapidly detects signs of pancreatic cancer

22 May 2018 | By Dr Zara Kassam (Drug Target Review)

A new diagnostic test developed by researchers at UC San Diego shows promise for detecting pancreatic cancer earlier...

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Zika may cause microcephaly by activating TLR3

6 May 2016 | By Victoria White, Digital Content Producer

Research shows that inhibiting this mechanism reduces brain cell damage, hinting at a new therapy to mitigating the effects of prenatal Zika virus infection...

news

Drug candidates protect neurons against damage from amyloid-beta

11 April 2016 | By Victoria White, Digital Content Producer

Chemists have designed a set of molecules that promote microscopic, anatomical changes in neurons associated with the formation and retention of memories...

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Injectible gel could be used to treat critical limb ischemia

9 March 2016 | By Victoria White

Critical limb ischemia causes extremely poor circulation in the limbs and leads to an estimated 230,000 amputations every year in North America and Europe...

news

Tamoxifen beats MRSA superbug in mice models

13 October 2015 | By Victoria White

Researchers have found that tamoxifen gives white blood cells a boost, better enabling them to respond to and kill bacteria in laboratory experiments...

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Researchers use KG5 to sensitise tumours to radiation and chemotherapy

4 September 2015 | By Victoria White

Researchers have identified a pathway that causes resistance to chemotherapy and radiation treatments and a new drug, KG5, that targets this pathway...

news

ESCMID publishes guidelines aimed at preventing build-up of biofilms

2 September 2015 | By Victoria White

ESCMID advocates the need for greater education, guidance and research on the build-up, treatment and prevention of biofilms...

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