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Ketogenic diet and a new cancer drug starves pancreatic cells
The discovery that eFT508 blocks eIF4E and the ketogenic pathway could provide the foundation for personalised therapies.
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UC San Francisco (UCSF)
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Identifying biomarkers for progressive supranuclear palsy
Protein biomarkers in spinal fluid linked to PSP could enable earlier diagnosis and treatment for this neurological disorder.
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Could scratching nerve cells be the itch solution?
The sensation of itch is something everyone has experienced at some point in their lives. It's a natural response to various irritants, from insect bites to dry skin. But what happens when the urge to itch becomes relentless, causing discomfort and, in some cases, serious health problems?
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Women in STEM with Michelle Arkin
Join us for our monthly Women in STEM series where we showcase and celebrate the achievements of inspiring women in the field. Step into the world of scientific innovation with Michelle Arkin, a visionary chemical biologist who leads the way as a Professor and Chair of Pharmaceutical Chemistry at UCSF.…
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Keeping T cells strong and improving cancer immunotherapy
The tumour microenvironment can prevent some T cells from carrying out their immunotherapeutic duties. In this Q&A, Dr Brian Shy, Clinical Instructor at the University of California, San Francisco (UCSF) Department of Laboratory Medicine, describes a recent study wherein he and fellow scientists discovered a strategy to strengthen T cells…
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Novel CAR T screens identify most effective cancer immunotherapy cells
Researchers have developed a new method for comparing CAR T cells, each with slightly different molecular features, to determine which is most effective and long-lasting against cancer.
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Scientists map networks of disease-associated immune genes
The new immune gene networks have implications for developing immunotherapies and understanding autoimmune diseases.
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New study reveals causes of stem cell transplant rejection
A new study has shown that mutations in mitochondrial DNA induced by cell reprogramming may trigger an immune response.
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Scientists mine gene responses to existing chemotherapies to facilitate precision cancer treatment
Scientists utilise computational biology techniques in a bid to enable doctors to use targeted therapies for cancer patients.
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DRD2 crystal structure provides antipsychotic drug development tool
Crystal structure of the dopamine 2 receptor bound to an antipsychotic drug provides a much-needed discovery in the quest to create effective drugs with fewer side effects...