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Increased persister cells production leads to antibiotic resistance
Using clinical E. coli bacteraemia isolates, researchers found that high-persister mutants evolved which contributed to antibiotic failure.
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UNC School of Medicine
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New understanding of the TMEJ pathway in cancer
Cancer treatment may be majorly impacted by new findings about the polymerase theta-mediated end joining time DNA repair pathway.
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Scientists discover the key to hepatitis A virus replication
With no current treatments for hepatitis A, scientists have discovered how a protein and enzymes interact to allow hepatitis A virus to replicate.
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Virtual drug discovery tackles unknown universe of drugs
An online compound library consisting of the structure of over a billion molecules could be the future of drug discovery...
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NLRP12 protein promotes healthy gut bacteria to curb obesity
Scientists have discovered that the anti-inflammatory protein NLRP12 normally helps protect mice against obesity and insulin resistance when they are fed a high-fat diet...
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Fragile X imaging study reveals differences in infant brains
For the first time, researchers have used MRIs to show that babies with the neurodevelopmental condition fragile X syndrome had less-developed white matter compared to infants that did not develop the condition...
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Study uncovers molecular events that reveal pathway toward heart disease therapy
Scientists from UNC-Chapel Hill and Princeton University in the United States, reveal key molecular details that hold promise for ultimate goal of heart disease reversal.
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DRD2 crystal structure provides antipsychotic drug development tool
Crystal structure of the dopamine 2 receptor bound to an antipsychotic drug provides a much-needed discovery in the quest to create effective drugs with fewer side effects...