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Researchers reveal frameshifting as SARS-CoV-2 drug target

14 May 2021 | By Victoria Rees (Drug Target Review)

A critical stage of the SARS-CoV-2 replication process, known as frameshifting, could be targeted by new drugs, researchers say.

SARS-CoV-2 - COVID-19 - inhibition by LY6E

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LY6E identified as potential immunoprotein against SARS-CoV-2

29 July 2020 | By Victoria Rees (Drug Target Review)

A study has demonstrated that the LY6E protein inhibits SARS-CoV-2 infection in human cell cultures, so a drug mimicking it could be a therapy for COVID-19.

Elderly person's hand holding a walking stick

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Rejuvenating the elderly and frail using eosinophils

9 July 2020 | By Hannah Balfour (Drug Target Review)

Researchers reveal a reduction in the number of eosinophil immune cells in belly fat with age may be the underlying cause of many age-related conditions with chronic low-grade inflammation.

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Researchers suggest animal experiments may be too standardised to be reproducible

5 June 2020 | By Hannah Balfour (Drug Target Review)

Experts suggest that increasing biological and conditional variations in their experiments could not only make them more reproducible but also reduce the total number of animals required.

article

If Columbus had a map… guiding the discovery of new drugs

4 June 2020 | By Horst Flotow (GDBspace), Jingwen Shi (GDBspace), Sacha Javor (GDBspace)

Exploring large databases and selecting compounds of interest can be extremely time-consuming for researchers. Here, Sacha Javor, Horst Flotow and Jingwen Shi discuss a novel chemoinformatics approach for drug discovery.

news

Gene identified in zebrafish effective at repairing heart damage

24 October 2019 | By Victoria Rees (Drug Target Review)

Researchers have discovered a gene in zebrafish that enables them to successfully recover after cardiac damage, which could be used to repair heart tissues in humans.

news

Using 3D cell cultures to fight anti-cancer therapy resistance

13 December 2017 | By Dr Zara Kassam (Drug Target Review)

An international team of researchers have developed 3D cell cultures in which genes can be specifically modified to improve the use of targeted anti-cancer drugs...

news

Intercontinental consortium granted €5.1 million to develop breast cancer imaging devices

15 September 2016 | By Niamh Louise Marriott, Digital Content Producer

Grants of more than €5 million, predominantly from the EU, will be used to develop a new imaging device for the diagnosis of breast cancer...

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