University of California San Diego School of Medicine

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DNA mutations shed in blood predicts response to immunotherapy

2 December 2017 | By Dr Zara Kassam (Drug Target Review)

Blood sample, or liquid biopsy, can reveal which patients will respond to checkpoint inhibitor-based immunotherapies...

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pIC found to prevent the development of liver cancer

14 November 2017 | By Dr Zara Kassam (Drug Target Review)

A synthetic double-stranded RNA has potential for use as an anti-liver cancer vaccine...

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CRISPR-Cas9 used to systematically inactivate genes in colorectal cancer

28 September 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have used CRISPR-Cas9 to inactivate genes in human colorectal cancer cell lines -- one with normal KRAS gene and one with a mutant KRAS...

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The fungal microbiome contributes to alcohol-induced liver damage in mice

23 May 2017 | By Niamh Marriott (Drug Target Review)

Alcoholism contributes to nearly half of liver cirrhosis-related deaths in the United States.

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Pathways leading to beta cell division identified, may aid diabetes treatment

4 May 2017 | By Niamh Marriott (Drug Target Review)

Pancreatic beta cells help maintain normal blood glucose levels by producing the hormone insulin -- the master regulator of energy (glucose). Impairment and the loss of beta cells interrupts insulin production, leading to type 1 and 2 diabetes.

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ALS study reveals role of RNA-binding proteins and provides new therapeutic target

20 October 2016 | By Niamh Louise Marriott, Digital Content Producer

To unravel the role RNA-binding proteins play in ALS, Yeo's team gathered skin cells from ALS patients, three with a mutation in the hnRNP A2/B1 gene...