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Genetic treatment reverses age-related memory loss in mice
Scientists have shown that manipulating the perineuronal nets (PNNs) in the brains of mice led to the reversal of age-related memory loss.
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Leeds University
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Reduced levels of H2S in rat brains protects against dementia
A study has shown that treatments to reduce levels of hydrogen sulphide (H2S) in the brain may help to prevent dementia.
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New insight to guide discovery of drugs targeting ion channels
The study shows how drug-like small molecules inhibit the activity of Transient Receptor Potential Canonical 1/4/5 (TRPC1/4/5) channels and could transform the development of future therapies.
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High-throughput screening for antibody-based drugs
A collaboration between academia and industry has produced an assay and new screening technique which utilises directed evolution for the discovery of antibody-based drugs.
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Scientists reveal structure of norovirus using cryo-EM
Researchers captured 13,000 images of a mouse norovirus using an electron microscope and compiled the images to reveal the structure of the virus.
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Master controller regions could be targeted for novel Parkinson’s therapies
Scientists have identified two master controller regions that are essential for alpha-synuclein aggregation and could be targeted by future therapies.
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‘Tricking’ bacteria could lead to more effective antibiotics
A technique to 'trick' bacteria into revealing pores in their cell walls has been developed and targeting these could make antibiotics more effective.
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Biomarkers to detect and prevent liver cancer
An increase in the expression of sugar-burning 'glycolytic' enzymes in precancerous cirrhotic livers has been identified and could be used as a biomarker...
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Chemical that can kill glioblastoma cells identified
"As an experimental chemical, further rigorous testing and refinement of KHS101 is required before trials in people can begin.”
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Old antibiotic compounds could become tomorrow’s life-saving drugs
Scientists and chemists are re-examining old compounds to see whether they could hold the key to a future drug to combat increasingly resistant bacteria...
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Inhibiting β-lactamase may reverse antibiotic resistance
By developing a chemical to inhibit β-lactamase enzymes, a significant proportion of antibiotic resistance may successfully be reversed...
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New synthetic polio vaccine candidate
A collaborative team of scientists have developed a novel synthetic vaccine with a method grown in plants that uses virus-like particles...
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Review: Biomarkers towards personalised therapy in cancer
Since the sequence of the human genome was published some 20 years ago, omics strategies have enabled the generation of detailed molecular signatures of cancers and their subtypes.
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Queen’s researchers breakthrough discovery in fight against bowel cancer
New research led by Queen’s University Belfast has discovered how a genomic approach to understanding bowel cancer could improve the prognosis and quality of life for patients.
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Discovery of ‘mini-brains’ could change understanding of pain medication
The human body’s peripheral nervous system could be capable of interpreting its environment and modulating pain, neuroscientists have established, after successfully studying how rodents reacted to stimulation.