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Breast cancer cells invade by a physical mechanism

15 November 2023 | By Drug Target Review

Findings from using a 3D hydrogel to study how cancer cells physically tear the basement membrane offers promise for targeted treatment.

news

What is the link between serotonin and heart valve disease?

3 February 2023 | By Izzy Wood (Drug Target Review)

US researchers found that serotonin impacts the mitral valve in the heart which can lead to heart valve disease.

article

How to block trogocytosis and improve CAR T-cell therapy

8 December 2022 | By Dr Serge Fuchs (University of Pennsylvania)

Blocking a process called trogocytosis could enhance the ability of CAR T-cell therapies to treat cancer, according to research led by University of Pennsylvania scientists. In this Q&A, Dr Serge Fuchs, Elizabeth and William Whitney Clark Professor of Oncology at the University of Pennsylvania School of Veterinary Medicine, US, discusses…

article

Drug Target Review Immuno-oncology ebook 2022

7 December 2022 | By Drug Target Review

In this ebook are articles on immune checkpoint inhibitors and enhancing CAR T-cell therapies.

news

Blocking trogocytosis improves ability of CAR T-cell therapy to treat cancer in mice

12 September 2022 | By Victoria Rees (Drug Target Review)

Researchers have found how tumours can avoid the immune system and cancer immunotherapies, including CAR T-cell therapies.

The silhouette of a blind man with a cane and glasses. People stand in a line and support the yellow figure by the hands.

news

Progress towards a stem cell-based therapy for blindness

1 August 2022 | By Ria Kakkad (Drug Target Review)

Scientists are developing an effective stem cell-based therapy to regenerate photoreceptors cells and restore sight in people with blindness.

Cancer patients receiving chemotherapy treatment in a hospital.

news

Discovered receptor that could alleviate the need for chemotherapy

11 July 2022 | By Ria Kakkad (Drug Target Review)

Researchers have shown that a synthetic IL-9 receptor allows T cells to fight against cancer without the need for chemotherapy or radiation.

news

Stem cell therapy repairs injured peripheral nerves in animal models

12 October 2021 | By Anna Begley (Drug Target Review)

Gingiva-derived mesenchymal stem cells were used to surgically repair injured peripheral nerves, showing potential for new therapies.

Blood smear under microscopy showing acute myeloid leukaemia (AML)

news

CRISPR screening tool exposes new leukaemia drug target

29 September 2021 | By Anna Begley (Drug Target Review)

A CRISPR screening tool identified a new target for acute myeloid leukaemia with fewer side effects than current approaches.

news

RN7SL1 RNA shown to activate T cells to fight against cancer

6 September 2021 | By Anna Begley (Drug Target Review)

A new study found that the RNA RN7SL1 can activate T cells to seek out cancer cells, potentially improving cellular treatments.

White blood cells as part of immune response to leukaemia

news

Existing drug may improve immune response to leukaemia treatment

18 August 2021 | By Anna Begley (Drug Target Review)

Researchers identified the inhibitor JQ1 as a potential drug to improve immune response to CAR T-cell therapies in leukaemia patients.

GABA possible treatment avenue of type 2 diabetes

news

Promising new avenue to tackle obesity-related diabetes

2 July 2021 | By Mandy Parrett (Drug Target Review)

New findings from collaborative research in the United States have identified a promising new treatment avenue for type 2 diabetes patients centring on the activity of the amino acid, GABA.

news

Novel mRNA vaccine provides full protection against malaria in mice

21 June 2021 | By Victoria Rees (Drug Target Review)

A new mRNA vaccine based on the malaria circumsporozoite protein was shown to elicit a robust immune response in mice.

news

Stem cell study illuminates cause of dilated cardiomyopathy (DCM)

2 February 2021 | By Victoria Rees (Drug Target Review)

A study using stem cells has revealed that DCM-causing mutations in LMNA disrupt the organisation of DNA in the nucleus of heart muscle cells.

news

Knee injection shows promise as osteoarthritis treatment in mice

18 January 2021 | By Victoria Rees (Drug Target Review)

Scientists have found that a new knee injection using nanomedicine could prevent the effects of osteoarthritis.

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