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CRISPR: three new developments in the world of gene editing
In this article, we outline three recent studies that have advanced the potential uses of CRISPR in the biomedical field.
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Pennsylvania University
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Enzyme vital for sperm formation potential target for male infertility
Researchers have identified an enzyme required for the formation of sperm and chromosomal pairing, which they say could be a target to treat male infertility.
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Study paves way for new vaccines to protect infants against infections
An mRNA vaccine has been developed which has elicited strong immune responses in mice in the presence of maternal antibodies.
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Study shows new strategies for HIV control
New research goes against the paradigm of HIV control that focuses on killing off infected cells and supports a model in which viral suppression could possibly serve as a cure.
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DTR’s news round-up 2019: the stories that defined the year
Drug Target Review lists its 10 most popular news stories from 2019, summarising the drug targets that you wanted to read about.
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HIV infant model opens new avenues for research
An animal model to test HIV infection in infants could lead to biomarkers that predict viral rebound after ART interruption.
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Interferon pathway could provide drug target for cancers
A study has found that signals from interferons can be blocked, allowing the immune system to attack tumours which provides a potential target.
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Longest successful gene expression raises hopes for gene editing therapies
A study has reported that genes delivered to rhesus monkeys are still being expressed four years later.
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Repurposing wasp venom as antibiotic drugs
Researchers have used wasp venom to create variants of a peptide that is potent against bacteria but nontoxic to human cells...
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Using anti-malaria drugs to slow tumour growth
Anti-malaria drugs, called chloroquines, target PPT1 from cancer cells, with researchers identifying how the drugs eliminate tumour growth in cancers...
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Tethered antibodies may prevent influenza virus infections
Investigational therapeutic candidate made with four antibodies tethered together shows promise against influenza A and B...
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RNA-seq of 20,000 cardiac cells reveals heart disease insights
RNA analysis of 20,000 cardiac cells from heart tissue in both ordinary and deceased mice showed an insight to the development of heart disease...
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Class of neurological disorders share 3D genome folding pattern
Researchers have found another common thread linking nearly all of the TNR expansion diseases...
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Research team develops predictor for immunotherapy response in melanoma
Researchers have developed a gene expression predictor that can indicate whether melanoma in a specific patient is likely to respond to treatment with immune checkpoint inhibitors...
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Brain cancer with mutation at EGFR alanine 289 may be susceptible to monoclonal antibody mAb806
Antibody mAb806 may be useful in treating aggressive forms of glioblastoma multiform...