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Elucidating MDLC’s molecular features
The study’s results indicate that spatial sequencing of mixed-type breast cancers could inform personalised treatment.
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University of Pittsburgh
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Explaining uveal melanoma’s resistance to conventional immunotherapies
Researchers have developed a new tool called ‘Uveal Melanoma Immunogenic Score’ to predict which patients will respond to adoptive therapy.
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A new genetic biomarker to predict immunotherapy success
Tumours with a greater IGR burden could respond better to immune checkpoint blockades, advancing precise treatments for patients.
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Novel class of antibodies can neutralise multiple strains of flu virus
The new antibodies can neutralise certain H1 and H3 strains with or without the 133a insertion, which could lead to improved vaccines.
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Potential of small molecule therapeutics for Barth syndrome
Novel findings about the tafazzin gene offers a potential new target and drug candidate for Barth syndrome.
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T cells’ vital role in boosting immune responses
In this article, Drug Target Review's Izzy Wood uncovers the cutting-edge breakthroughs in T cell research that are revolutionising our understanding of the immune system and paving the way for new therapies and treatments.
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Genomic sequencing helps find treatment for rare genetic skin disorder
US researchers use genome sequencing to reveal genetic basis for disabling pansclerotic morphea, a severe inflammatory disease.
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Customising T cell-based immunotherapies to treat cancers
US researchers usings a ‘SNAP’ receptor system can customise immunotherapies for targeted treatments of cancer and other diseases.
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Helper T cells may hold key to precision allergy treatment
US researchers have connected a rare T cell called Th9 with treating allergies, testing in mouse models with asthma.
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The role of ABCs in lupus: insights for developing precision therapies
Researchers from the University of Pittsburgh have found that age-associated B cells (ABCs) are key drivers of lupus, a chronic autoimmune disorder that attacks the patient's own organs.
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Nanotechnology: a new immuno-onocology weapon
This article outlines three innovative studies that use nanotechnology to deliver a new immunotherapy approach towards cancers.
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Novel nanoparticles deliver innovative cancer chemoimmunotherapy
University of Pittsburgh researchers have designed cancer-fighting nanoparticles that co-deliver a chemotherapy drug and a novel immunotherapy
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Researchers discover clues on how cells control their volume
A new study from the University of Pittsburgh and Carnegie Mellon University may solve the puzzle of how cells control their volume.
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Using computational modelling to gain insights into flu viruses
Scientists at the University of Pittsburgh have been using computational modelling to understand the body’s immune responses to avian flu.
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Algorithm identifies cancer drugs to treat pulmonary hypertension
Scientists have identified potential cancer drugs to treat pulmonary hypertension using experimental and computational approaches.