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Scientists elucidate the mechanism behind middle-aged obesity

14 March 2024 | By Drug Target Review

New findings show that age-related MC4R+ cilia shortening causes middle-aged obesity and leptin resistance, which could lead to obesity treatment.

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New method of designing drugs without side effects

8 June 2023 | By Izzy Wood (Drug Target Review)

Japanese researchers now reveal a new way of activating GPCR by triggering shape changes in the intracellular region of the receptor. This new process can help researchers design drugs with fewer or no side effects.

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Study suggests how to develop intranasal vaccines for COVID-19 and flu

30 August 2021 | By Anna Begley (Drug Target Review)

New research has explored the role of nasal bacteria to better develop intranasal vaccines for viruses such as COVID-19 and flu.

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Technique developed for delivery of iPSCs to treat type I diabetes mellitus

6 April 2021 | By Victoria Rees (Drug Target Review)

A team has developed a lotus-root-shaped construct to deliver iPSC-derived pancreatic beta-cells to patients with type I diabetes mellitus.

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Novel enterocyte-like cells developed by researchers from stem cells

8 February 2021 | By Victoria Rees (Drug Target Review)

A team has developed enterocyte-like cells from hiPSCs, which can be used to study the absorption of novel oral drugs.

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Gramicidin A antibiotic analogues safe for human cells developed

6 October 2020 | By Victoria Rees (Drug Target Review)

A team has developed 10 new versions of the antibiotic gramicidin A, which they say should be safe for use in pills or injections.

A microscopy image of neuromuscular junctions with projections from the neurons (grey/black) connecting to the muscles (purple).

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Age-related decline in motor function could be prevented using gene therapy

19 August 2020 | By Hannah Balfour (Drug Target Review)

Enhancing neuromuscular junction (NMJ) formation using DOK7 gene therapy improved muscle strength and motor function in aging mice.

face mask, white tablets and syringe of medication

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Nafamostat inhibits SARS-CoV-2 infection, preventing COVID-19 transmission

31 March 2020 | By Hannah Balfour (Drug Target Review)

Researchers have demonstrated that Nafamostat mesylate (Fusan) can inhibit SARS-CoV-2 Spike protein-initiated membrane fusion at concentrations likely achievable and safe in patients.

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Synthetic molecules could provide new antibiotics

8 July 2019 | By Victoria Rees (Drug Target Review)

Using a novel technique, researchers have created new molecules effective at killing bacteria, providing new antibiotic drug targets.

news

New nanomachines developed to deliver cancer drugs to hard-to-reach areas

29 April 2019 | By Drug Target Review

In a recent study in mice, researchers have found a way to deliver specific drugs to parts of the body that are exceptionally difficult to access.

news

Clearest image of Ebola virus protein gained by researchers

18 October 2018 | By Drug Target Review

Researchers collaborated to identify the clearest image of the Ebola virus protein ever obtained using a cryo-electron microscope...

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