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INPP4B exerts its tumour-promoting effects via lysosomes
Researchers have uncovered a how INPP4B, alongside PIKfyve and TRPML-1, drives pancreatic cancer metastasis.
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Toronto University
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Improved method to control the generation of dopaminergic neurons
A synthetic antibody selectively activates the Wnt signalling pathway and directs stem cells to differentiate into neurons.
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Conformational equilibria in GPCRs provides clues about activation
Having revealed the activation mechanism and functional states of A2AR signalling, a GPCR, researchers say this could aid drug discovery.
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Inhibiting enzyme could provide strategy to halt glioblastoma growth
A study has shown that inhibiting the enzyme PRMT5 can suppress the growth of glioblastoma cells in pre-clinical studies.
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New bioprocess generates haematopoietic stem and progenitor cells
A new single-use, closed-system upstream bioprocess has been developed which enables the production of large number of haematopoietic stem cells and progenitor cells.
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Screening reveals rocaglate compounds kill C. auris
Researchers have screened over 2,000 compounds to discover that rocaglates effectively combat C. auris, offering a potential new treatment.
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CRISPR development enables simultaneous gene editing
Using a combination of Cas9 and Cas12a, Canadian researchers have enabled CRISPR methods to edit multiple genes at the same time.
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MaveDB: database to aid research into genetic causes of disease
Researchers in Australia and the US have launched the first open-source database detailing genetic variants that impact human health and disease.
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Device using small biomagnets could result in faster drug discovery
A new platform brings together genome editing with magnetic cell sorting to reveal new drug targets for cancer and regenerative medicine.
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AI algorithm accurately predicts Alzheimer’s disease onset
Scientists have developed an algorithm that can more accurately predict cognitive decline that leads to Alzheimer’s disease. Early preventive measures may help delay and even halt the disease’s onset.
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Breast cancer could be prevented by targeting epigenetic proteins
Researchers have discovered that epigenetic proteins promote the proliferation of mammary gland stem cells in response to the sex hormone progesterone.
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Artificial gene defect reveals target to fight genetic disease
Scientists have deployed a novel genetic screen to search for synthetic viable interactions on special lines of Fanconi Anaemia-defective cells...
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Mirror-image peptides of existing drugs provide longer-lasting therapeutic effects
Researchers have developed a new technology for creating more durable disease-fighting molecules which could lead to drugs with longer-lasting effects...
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Final numbers are in: 42 million protein molecules in a yeast cell
Researchers have officially revealed the abundance of protein molecules in a single cell runs into the tens of millions: around 42 million, to be precise.
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Shedding light on the role of the immune system in schizophrenia
20 July 2016 | By Victoria White, Digital Content Producer
It had been suspected that the illness was an autoimmune disorder but now scientists have found strong evidence that schizophrenia is different...