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New trivalent vaccine for clade 1 sarbecoviruses
The vaccine provided complete protection with no detectable virus in the lungs and could be a routine part of people’s medical treatment.
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Mitigating oxidative stress in neurodegenerative diseases
Researchers have found that using protein-like polymers to inhibit the Keap1/Nrf2 PPI is a powerful therapeutic strategy.
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iPSC-derived cells can augment remuscularisation of the heart
Researchers have improved the method of regenerating heart muscle after a heart attack using a combination of iPSC-derived cells.
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Midbody remnants following mitosis could combat cancer
Midbody’s role in cell signalling and stimulating cell proliferation offers an opportunity to detect cancer.
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New insights into influenza A’s infiltration of host cells
US researchers have made a significant breakthrough in understanding how the influenza A virus takes over host cells while minimising damage to itself. By studying the protein PA-X, they found that the virus uses a surgical strike approach, selectively degrading host cell RNA while preserving its own replication, shedding light…
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Newly identified cell type could be key to preventing graft versus host disease
UW researchers at the Carbone Cancer Center have identified the cells that can cause graft versus host disease, the most common complication of bone marrow transplants.
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Biodegradable gel boosts immune system’s attack on several cancers in mice
A new biodegradable gel can release drugs and special antibodies that simultaneously deplete macrophages from the surgical site and activate T cells.
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NPSR1 gene discovered as a key cause of endometriosis
NPSR1 has been identified as a genetic cause of endometriosis, revealing a potential drug target that may lead to better therapies.
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Radiopharmaceuticals and nanoparticles used to kill cancer cells
Researchers have developed a potential cancer treatment using light from radiopharmaceuticals and polymer nanoparticles to kill cancer cells.
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Team uses antibodies to tag disease-related proteins for destruction
Researchers have developed a technique utilising antibodies to tag disease-causing proteins, to treat the underlying causes of disease.
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Over 200 molecules and genes linked to COVID-19 severity
A team has identified 219 molecules and genes that influence the severity of COVID-19 in patients, providing information that could aid the development of therapeutics.
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Researchers identify potential drug target for depression in primates
A study has discovered a molecule key in neuronal growth that could be used as a drug target to treat anxiety-related diseases.
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Study suggests immune cells play vital role in fungal disease
New research has revealed the immune cells may be critical in moving pathogenic fungal spores to the central nervous system, pointing to drug target.
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Efficacy of breast cancer therapy measured using PET imaging
Researchers have developed a method using PET imaging along with 18F-fluorofuranylnorprogesterone to analyse the efficacy of breast cancer treatments...
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CRISPR repurposed to develop better antibiotics
Mobile-CRISPRi could be used to guide gene expression, in turn control levels of proteins produced, enabling scientists to identify key antibiotic targets...