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Vanderbilt University

Man with inflammatory bowel system holding his stomach highlighted in red

news

CRISPR screen unveils enzyme target for inflammatory diseases

19 November 2021 | By Anna Begley (Drug Target Review)

Scientists used a CRISPR-based screen to find that inhibiting MTHFD2 reduces disease severity in inflammatory disease models.

article

Identifying a novel treatment for heart attacks

25 March 2021 | By Victoria Rees (Drug Target Review)

Professor David Merryman explains how his team targeted the serotonin 2B receptor in animal models to preserve cardiac function six weeks after a heart attack.

news

Experimental mAb subdues type 1 diabetes in laboratory mice

23 February 2021 | By Victoria Rees (Drug Target Review)

A monoclonal antibody given to mice reversed type 1 diabetes by suppressing the actions of glucagon, a study has shown.

3D illustration of a tumour cell under cross hares

article

NOX5: a novel target for sensitising melanoma to therapies

19 February 2021 | By Hannah Balfour (Drug Target Review)

Vito Quaranta, professor of biochemistry and pharmacology, discusses how cancerous cells adopting novel mechanisms of energy production could be sensitised to existing therapies with a focus on melanoma.

news

Targeting the HCF-1 protein causes cancerous cells to self-destruct

1 February 2021 | By Hannah Balfour (Drug Target Review)

Disrupting the interaction between the MYC oncogene and its co-factor, host cell factor (HCF)–1, was sufficient to cause Burkitt’s lymphoma cells to self-destruct in vivo.

Mouse in lab - Translating novel drug success in animals to humans

article

Translating novel drug success in animals to humans

12 August 2020 | By Victoria Rees (Drug Target Review)

A team has developed a predictive tool called TransComp-R which could be used to reveal whether new drugs that have been effective in animals will have positive outcomes in humans.

news

New approach shows regeneration of severely damaged lungs

7 May 2019 | By Drug Target Review

Researchers are first to demonstrate in a clinically relevant model that damaged lungs can be regenerated to meet transplantation criteria.

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Vanderbilt University

CRISPR screen unveils enzyme target for inflammatory diseases

Identifying a novel treatment for heart attacks

Experimental mAb subdues type 1 diabetes in laboratory mice

NOX5: a novel target for sensitising melanoma to therapies

Targeting the HCF-1 protein causes cancerous cells to self-destruct

Translating novel drug success in animals to humans

New approach shows regeneration of severely damaged lungs