article
Nuclear Magnetic Resonance as a tool for chemokine inhibitor discovery
Chemokines orchestrate leukocyte trafficking in the immune system, but unregulated…
Chemokines orchestrate leukocyte trafficking in the immune system, but unregulated or inappropriate chemokine activity plays a key role in many inflammatory, allergic and autoimmune diseases as well as metastatic tumour progression. The chemokine network is comprised of ~50 distinct ligands that specifically bind and activate a family of 20 G…