Dr Jia-Jia Zhang (Fourth Military Medical University)

The promise of 3A5C7 mAb in the treatment of morphine tolerance

Morphine is a frequently used analgesic that activates the mu-opioid…

30 January 2024 | By Dr Jia-Jia Zhang (Fourth Military Medical University), Ellen Capon (Drug Target Review)

Morphine is a frequently used analgesic that activates the mu-opioid receptor (MOR), which has prominent side effects of tolerance. A monoclonal antibody (mAb) precisely targeting MOR, named as 3A5C7, was developed to treat morphine tolerance by enhancing morphine-induced MOR endocytosis via GRK2/β-arrestin2 pathway. In this Q&A session with Dr Jia-Jia…

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Dr Jia-Jia Zhang (Fourth Military Medical University)

The promise of 3A5C7 mAb in the treatment of morphine tolerance