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Drug screening reveals pralatrexate could be repurposed to treat COVID-19
Computational drug screening has shown that chemotherapy drug pralatrexate could potentially be repurposed to treat COVID-19.
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Imaging, sequencing & screening
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COVID-19 drug development based on boosting immunity
Baidyanath Dash explains the two requirements for COVID-19 drug development: killing the virus and boosting immunity.
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A computational effort to deciphering putative COVID-19 3C-like protease binders
Dr Isaac Karimi and his team explain how compounds to treat COVID-19 could be found in Kurdish ethnomedicine, selecting some plants for computational drug discovery.
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ACE2 protein protects against severe COVID-19 in women, study shows
According to new research, because women have two copies of the ACE2 protein, they are less likely to suffer from severe COVID-19, unlike men who have one copy.
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Assay reveals potency of neutralising antibodies in COVID-19 patients
Researchers have shown that neutralising antibodies developed in COVID-19 patients were less potent if from those with severe or fatal disease.
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RNA sequencing provides insights into why every SARS-CoV-2 infection is different
Associate Professor Pandurangan Vijayanand from La Jolla Institute for Immunology discusses his study into the body’s immune response to SARS-CoV-2 and why this can vary.
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Biomarkers for predicting COVID-19 disease severity
Scientists have created a prognostic classification model which uses biomarkers to help predict an individual’s risk of developing severe COVID-19 symptoms.
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New SARS-CoV-2 strain identified in South East England
UK Health Secretary Matt Hancock has said there is a mutated form of SARS-CoV-2 that may be causing a rise in infections in South East England.
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Genome-wide association study reveals targets for COVID-19 treatments
The study found five key genetic differences when they compared sequences from severe COVID-19 patients to healthy individuals.
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Biomarker for blood vessel damage found in children with SARS-CoV-2
Elevated levels of a biomarker related to blood vessel damage have been found in all children with SARS-CoV-2 infection.
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Triggering an IgA response could increase COVID-19 vaccine efficacy
Two new studies suggest that SARS-CoV-2-specific IgA antibodies are more neutralising and therefore COVID-19 vaccines should encourage an IgA response.
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Microscopy reveals four classes of SARS-CoV-2 neutralising antibodies
Researchers show that neutralising antibodies targeting the SARS-CoV-2 Spike protein have four distinct structures.
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Researchers provide new insights into SARS-CoV-2 lung pathology
The new study shows how SARS-CoV-2 significantly remodels cellular processes in just an hour and identifies potential drug targets and therapeutics for COVID-19.
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Tracking SARS-CoV-2 with genome sequencing
Researchers have been tracking SARS-CoV-2 by sequencing the genomes of virus samples collected from diagnostic testing. They hope that using next-generation sequencing (NGS) on SARS-CoV-2 will help to accurately diagnose the novel coronavirus, identify mutations and track its history. This article explores the findings of their latest study and what…
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Predicting COVID-19 susceptibility and severity
Recent reports suggest that both clinical and genetic risk factors may contribute to COVID-19 susceptibility and severity. Catherine Ball, Chief Scientific Officer of Ancestry®, discusses results of the company’s COVID-19 Research Study, designed to explore non-genetic and genetic associations with disease outcomes.
