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Team suggest bradykinin system could be targeted by COVID-19 drugs
Researchers say computational analyses suggest the bradykinin system may explain some of the symptoms of COVID-19, providing a drug target.
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Imaging, sequencing & screening
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High-throughput screening reveals 21 drugs with activity against COVID-19
After screening 12,000 existing drugs, scientists have identified 21 which prevent the replication of SARS-CoV-2 in concentrations safe for patients.
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Could the Nsp1 protein be a novel drug target for COVID-19?
A study of the SARS-CoV-2 nonstructural protein 1 (Nsp1) showed it can supress translation and inhibit anti-viral defence mechanisms, making it a potential target for drugs.
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Genomics England launches next-generation research platform
The genomic research platform will initially be used to help fast-track COVID-19 drug research and development, before being leveraged against other diseases, such as cancer.
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Six molecular targets for COVID-19 identified by researchers
A study of blood samples from COVID-19 patients has allowed a team to reveal six molecular targets that could be used to develop treatments for the virus.
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X-rays reveal structure of SARS-CoV-2 protease at room temperature
Researchers grew large crystals and used an X-ray machine with a less intense beam to elucidate the structure of the SARS-CoV-2 main protease at room temperature.
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Study identifies 68 genes associated with risk of severe COVID-19
A study has revealed 68 protein-coding genes associated with risk of severe COVID-19, nine of which are targeted by drugs currently in clinical trials.
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Promising COVID-19 drug candidate identified by virtual screening
After virtually screening 640 existing drug compounds, researchers have revealed that PC786 potently targets several SARS-CoV-2 receptors, making it a candidate to fight COVID-19.
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Open source all-atom model of entire COVID-19 S protein released
Researchers have developed a video and model-building programme for other scientists to build full-length COVID-19 S protein models.
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N terminal domain of S protein revealed as antibody target for COVID-19
An antibody with high neutralising potency against SARS-CoV-2 that binds to the N terminal domain of the Spike protein has been identified by a team researching COVID-19 therapeutics.
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Method to convert any mouse into COVID-19 model made available to researchers
Researchers who reported that delivering the human ACE2 protein into mouse airway cells creates COVID-19 models have released their findings to allow other scientists to make their own models.
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Biomarker suggests COVID-19 could cause brain injury in patients
Researchers have found that a neurofilament named NfL is heightened in COVID-19 patients who require ventilator treatment, so could serve as a biomarker for the disease.
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Screening reveals nelfinavir and amodiaquine combat COVID-19 in cell cultures
Researchers who screened 136 broad-spectrum antivirals identified six with the most activity against COVID-19 and an optimum combination of two to fight the virus.
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Online tool allows researchers to track genetic structure of SARS-CoV-2
An artificial intelligence platform available online has been designed to help researchers track the genetics of SARS-CoV-2 as it moves from person to person.
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SARS-CoV-2 immunodominant epitopes identified as vaccine candidates
Researchers have analysed the SARS-CoV-2 proteome to reveal seven promising immunodominant epitopes that could aid in the development of a COVID-19 vaccine.