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Multivalent carbohydrate-binding modules show efficacy against COVID-19
Tested on plaque reducing assays, researchers have identified a lead candidate multivalent carbohydrate-binding module for the treatment of COVID-19.
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Therapeutics
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Researchers identify monoclonal antibody to neutralise COVID-19
An antibody that neutralises both SARS-CoV and SARS-CoV-2 in cell cultures has been discovered by researchers and could be used to treat COVID-19.
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Cytokine storms and T-cell counts may offer clues on COVID-19 treatment
According to a new study, treatments for COVID-19 should focus on cytokines and T-cell counts and their function, rather than patient respiratory function.
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Intravenous immunoglobulins, hyperimmunes and pandemic viruses
David Johnson of GigaGen discusses how recombinant forms of intravenous immunoglobulins (IVIG) could overtake current IVIG therapies and be used in the treatment of COVID-19.
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Researchers reveal cryo-EM structure of remdesivir bound to SARS-CoV-2
A group of researchers has used cryo-EM to discover the structure of the remdesivir-bound RNA complex of SARS-CoV-2 and explain how the drug inhibits COVID-19 viral replication.
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Three new assays to test COVID-19 antivirals developed
A series of three new assays to screen for drug compounds or proteins that combat the COVID-19 coronavirus has been developed.
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Antibodies developed from llama show promise in fighting COVID-19
Engineering antibodies found in a llama, researchers have developed a potential COVID-19 therapy which they say can neutralise SARS-CoV-2.
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Developing respiratory therapeutics for prophylaxis and treatment
Drug Target Review explores antiviral Fc-conjugates and how they could be used as a COVID-19 prophylactic and therapeutic with Dr Jeff Stein, Cidara’s President and CEO.
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AI platform developed to rapidly identify treatment regimens for infections, including COVID-19
A new AI tool has been created by researchers to identify the best treatment courses and doses for bacterial or viral infections, such as COVID-19.
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Multidrug nanoparticles developed for treatment of COVID-19 inflammation
Multidrug nanoparticles for the targeted delivery of drugs could be used to combat inflammation in COVID-19 patients, say researchers.
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NIAID releases strategic plan, outlining COVID-19 research priorities
The US National Institute of Allergy and Infectious Diseases (NIAID) plan outlines four research priorities, including furthering understanding of SARS-CoV-2 viral transmission and pathogenesis and development of animal models.
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Cytokine storms: a major killer in patients with severe COVID-19 infection
Professor Saad Shakir explains why cytokine storms occur in COVID-19 patients and suggests potential therapies for the symptoms of the coronavirus.
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Natural peptides versus COVID-19
Peptides could serve as a potential platform for development of novel drugs for the treatment of the COVID-19 coronavirus.
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Fundamental molecular research underpins our ability to combat COVD-19, says article
Ali Shilatifard’s article explains how investment in institutes performing molecular research is essential, as it is the foundation for all attempts to combat COVID-19 and other future pandemics.
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Lead SARS-CoV-2 inhibitor compound identified by researchers to treat COVID-19
Researchers have found a lead compound which they say inhibits SARS-CoV-2 viral replication and demonstrates good pharmacokinetic activity in vivo.