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Novel protein could neutralise SARS-CoV-2 infection in kidneys

2 February 2021 | By Victoria Rees (Drug Target Review)

A new protein can trick SARS-CoV-2 and bind to the Spike protein rather than cell membranes in a kidney organoid.

Coronavirus particles in green with purple extracellular proteins

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N439K variant of SARS-CoV-2 is resistant to some neutralising antibodies, shows study

1 February 2021 | By Hannah Balfour (Drug Target Review)

The N439K mutation improves the interaction between SARS-CoV-2 Spike protein and the viral receptor ACE2 and eludes antibody-mediated immunity, say investigators.

SARS-CoV-2 spike protein bound to an ACE2 receptor on the cell surface

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Heparin inhibits SARS-CoV-2 invasion, finds study

29 January 2021 | By Hannah Balfour (Drug Target Review)

Research suggests heparin could be repurposed for COVID-19 because it can bind to the SARS-CoV-2 Spike protein and prevent the virus from infecting cells in vitro.

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Melatonin could act as barrier against SARS-CoV-2 infection

28 January 2021 | By Victoria Rees (Drug Target Review)

Researchers have suggested using melatonin in a nasal spray to create a protective barrier against SARS-CoV-2 in pre-symptomatic patients.

white antibodies attacking an orange coronavirus particle with yellow neuraminidase proteins on its surface

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Novel antibody candidate could offer pan-coronavirus protection

26 January 2021 | By Hannah Balfour (Drug Target Review)

The lead candidate, ADG2, was able to neutralise SARS-CoV and various strains of SARS-CoV-2, including those that are resistant to currently available antibody treatments.

Blue and white caspsules - potentially NSAIDs - on a yellow background

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NSAIDs could be damaging to COVID-19 patients, dependent on timing, suggests study

25 January 2021 | By Hannah Balfour (Drug Target Review)

In murine models of COVID-19, researchers found that non-steroidal anti-inflammatory drugs (NSAIDs) can suppress the inflammatory response and production of antibodies.

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Novel nanobody combinations protect cells from SARS-CoV-2 in vitro

14 January 2021 | By Hannah Balfour (Drug Target Review)

By combining nanobodies targeting different regions of the SARS-CoV-2 Spike protein, researchers were able to protect cells from infection.

yellow SARS-CoV-2 particles in a black alveoli

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Novel human alveolar tissue model could help COVID-19 drug development

12 January 2021 | By Hannah Balfour (Drug Target Review)

Researchers will use the in vitro model to study how respiratory viruses, like SARS-CoV-2, cause Acute Respiratory Distress Syndrome (ARDS) and develop potential interventions.

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Drug screening reveals pralatrexate could be repurposed to treat COVID-19

4 January 2021 | By Victoria Rees (Drug Target Review)

Computational drug screening has shown that chemotherapy drug pralatrexate could potentially be repurposed to treat COVID-19.

SARS-CoV-2 particle surrounded by red blood cells in a blood vessel - idea of COVID-19 causing blood clots

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Opaganib shows promise in preventing ARDS-induced thrombosis

16 December 2020 | By Hannah Balfour (Drug Target Review)

Opaganib reduced blood clot length and weight in a pre-clinical model of Acute Respiratory Distress Syndrome (ARDS).

red coronavirus particles next to blue DNA strands

news

Genome-wide association study reveals targets for COVID-19 treatments

14 December 2020 | By Hannah Balfour (Drug Target Review)

The study found five key genetic differences when they compared sequences from severe COVID-19 patients to healthy individuals.

news

Oral drug blocks SARS-CoV-2 transmission in ferrets, researchers find

4 December 2020 | By Victoria Rees (Drug Target Review)

A team has found that their drug Molnupiravir (MK-4482/EIDD-2801) acts as an antiviral against SARS-CoV-2 in pre-clinical studies.

purpley-blue antibodies surrounding a red and black SARS-CoV-2 viral particle

news

Microscopy reveals four classes of SARS-CoV-2 neutralising antibodies

4 December 2020 | By Hannah Balfour (Drug Target Review)

Researchers show that neutralising antibodies targeting the SARS-CoV-2 Spike protein have four distinct structures.

cartoon of blue coronavirus particles surrounding pink human lungs - idea of SARS-CoV-2 lung pathology

news

Researchers provide new insights into SARS-CoV-2 lung pathology

3 December 2020 | By Hannah Balfour (Drug Target Review)

The new study shows how SARS-CoV-2 significantly remodels cellular processes in just an hour and identifies potential drug targets and therapeutics for COVID-19.

white lab mouse sat in a petri dish held in a researcher's gloved hands

news

Novel peptide therapy improves COVID-19 survival by LEAPS and bounds in mice

3 December 2020 | By Hannah Balfour (Drug Target Review)

Researchers report that their LEAPS COV-19 peptides significantly improved survival in a murine model of COVID-19.

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Therapeutics