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Elucidating the aggregation rules for short peptides
The findings could aid the design of more stable drugs and improve the understanding of diseases linked to peptide aggregation.
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Amino Acids
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Novel version of CRISPR gene-editing protein engineered
Researchers have developed a new, compact EbCas12a variant that can be packaged into an all-in-one AAV system with its crRNA.
news
New insights into PD-1 formation could greatly improve treatments
A single change in the amino acid structure of the transmembrane segment can either enhance or diminish the inhibitory function of PD-1 in immune responses.
article
Breakthrough for pancreatic cancer treatment
Researchers have designed the first small molecule drug targeting K-Ras GD12, which could improve pancreatic cancer outcomes.
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Therapeutic peptide developed for triple-negative breast cancer
Scientists demonstrate how disrupting the Cx26 molecular complex in triple-negative breast cancer cells slowed tumour growth.
news
How breast cancer cells take advantage of the extracellular matrix
Researchers discover a key metabolic process that cancer cells use to grow in a nutrient deprived environment, which could be a new target.
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CBPUV nanoparticles show excellent anticancer activity
Novel self-assembled amino acid-based nanoparticles, loaded with doxorubicin, could evolve cancer treatment.
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AI system produces binding proteins using limited target information
New software can make protein molecules that bind with high affinity and specificity to many biomarkers, including human hormones.
news
Scientists discover extensive array of protein folds unexplored in nature
A study out of Japan reveals diversity of protein structures and how they fold in nature, uncovering a myriad of protein topologies.
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DNA technology helps slow down and scan molecules multiple times
Swiss researchers have achieved near-perfect control over the manipulation of individual DNA molecules, allowing them to be identified and characterised with unprecedented precision
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Amino Acid PET effective in distinguishing brain metastases from treatment-related changes
US study uncovers the best way to treat recurrent or progressive brain metastases using an amino acid PET technique.
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Diagnosing inflammatory diseases with synthetic peptides
Researchers from Switzerland identify peptides that detect and measure a key biomarker in inflammatory conditions.
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SARS-CoV-2 spike protein dihedral angle oscillations reveal favoured rotation frequencies
As new variants of the SARS-CoV-2 virus emerge, leading scientists Dr Oscar Bastidas and Dr Zoran Sevarac explore how their latest research identified a structured frequency domain profile in data with no discernible pattern. Their article also emphasises that it remains imperative to continue learning about this pathogen’s molecular machinery…
news
Scientists develop an AI model to make enzyme engineering more efficient
Researchers have streamlined the traditionally slow process of enzyme engineering. This work might help researchers tailor the suitability of enzymes for custom purposes.
whitepaper
Product hub: High-throughput screening of cyclic peptide libraries for developing drugs to challenging targets
Professor Christian Heinis explains how peptides could offer the next generation of therapeutics and what is required to screen libraries of cyclic peptides.