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Novel antibiotic peptide fights ‘superbug’ lung infections in mice
Scientists have developed a new antimicrobial peptide therapy named D8 with high efficacy and low toxicity in mice which could be used to fight lung infections.
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Antibiotics
Antibiotics are a type of antimicrobial drug used in the treatment and prevention of bacterial infections.
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MERS vaccine candidate could hold promise for COVID-19 vaccine
The vaccine candidate protected all murine models from a lethal MERS infection and could also be effective against the SARS-CoV-2 virus causing COVID-19.
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CRISPR discovery could be used to combat multi-drug resistant bacteria
A study has shown that plasmids use type IV CRISPR-Cas against competing plasmids, leading the researchers to suggest the method as a novel way to tackle multi-drug resistant bacteria.
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Cannabidiol identified as potential ‘helper’ compound for antibiotics
Researchers have found that using antibiotics in combination with cannabidiol (CBD) enhanced their effect against Staphylococcus aureus bacteria.
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Blocking bacterial competence could prevent antibiotic resistance
Scientists suggest competence-blocking, ‘anti-evolution’ drugs could be administered alongside antibiotics to prolong the period before bacterial resistance emerges.
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Compound effective against bacterial superbugs discovered
Researchers have developed a compound, called AB569, effective at combatting bacteria such as Pseudomonas aeruginosa and have revealed its mechanism of action.
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Novel antibody breaks bacterial biofilms and prevents sepsis in mice
A new monoclonal antibody has been discovered which disassociates bacterial biofilms and stops bacteria from entering into circulation has been tested in mice.
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Metal-containing compounds could lead to new antibacterials
International collaboration has shown that compounds with metals in them show antibacterial activity against MRSA, E. coli and A. baumannii.
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New T-cell discovery could lead to treatments for both bacterial infections and autoimmune conditions
A novel highly activated form of T cells could be suppressed to treat autoimmune conditions and activated in treating bacterial infections.
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New study helps improve the understanding of bacteria and viruses
A new study has revealed how bacterial immune systems can be harmful for their hosts and why they are not found in all bacteria.
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Coronavirus update: recent developments in vaccine research
Drug Target Review’s round-up of the latest developments in 2019 novel coronavirus (COVID-19 or SARS-CoV-2) therapeutics and vaccines.
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Compound combination successful against Pseudomonas aeruginosa
Researchers have developed a new combination of compounds called AB569 which has demonstrated success at fighting deadly pathgoens like Pseudomonas aeruginosa.
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Novel antibiotic compound revealed through artificial intelligence screening
A new antibiotic compound has been identified by researchers who designed a machine-learning algorithm to screen millions of molecules.
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Class of antibiotics with unique mechanism to combat bacteria discovered
Researchers have uncovered new antibiotics which prevent bacteria from multiplying, offering a strategy to fight infections.
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Researchers develop screening platform to detect new antibiotics
A new technology developed by scientists combines small molecule screening methods with machine learning algorithms to identify novel antibiotics that inhibit ribosomes.