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Novel antibody breaks bacterial biofilms and prevents sepsis in mice
A new monoclonal antibody has been discovered which disassociates bacterial biofilms and stops bacteria from entering into circulation has been tested in mice.
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Antibodies
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Why invest in creating a modifiable drug framework?
Drug Target Review spoke with CUE Biopharma’s President and CSO to find out how and why they created the ImmunoSTAT platform and the ways it may benefit drug design in the future.
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Targeting CD36 with antibody inhibits Treg tumour protection in mice
Researchers have discovered that an antibody which targets the CD36 protein prevents Tregs from protecting tumours against immunotherapies in mouse models.
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B cells may travel to remote areas of the brain to improve stroke recovery
Research has found that after stroke in mice, B cells migrate to far regions of the brain that control motor functions, indicating their role in recovery.
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Scientists can now ‘listen in’ on cancer cells with new technique
More effective drugs could be developed due to a new technique that has allowed scientists to decipher how millions of individual cells are communicating with each other on miniature tumours grown in a lab.
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RNA methylation knock-out mutant could be potential HMPV vaccine
Research has shown that human metapneumovirus uses RNA methylation to hide from the immune system and that knocking out this methylation creates a mutant strain which acts like a vaccine.
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Inflammatory molecules for controlling capillary loss discovered
Scientists have discovered three major pro-inflammatory mediators that drive capillary loss and identified drug combinations to prevent the degeneration of these tiny blood vessels.
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Tobacco mosaic virus creates novel malaria vaccine candidate
Researchers in the United States have used particles from the tobacco mosaic virus (TMV) to produce a new much-needed malaria vaccine.
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Study identifies gene responsible for T follicular helper cell development
A loss-of-function mutation in the Prkd2 gene has been revealed as a driver of T follicular helper cell development which could be useful for vaccine design.
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Could Frizzled receptors be the target of new cancer therapeutics?
The G-protein coupled receptor Frizzled, implicated in diseases like cancer, can be targeted with small molecules which could provide the basis for anti-cancer therapeutics, according to researchers.
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Researchers find VISTA molecule silences immune system against cancer
A new study shows that the VISTA molecule stops the immune system responding to self-antigens, including those presented by cancer cells, so an anti-VISTA antibody could be a possible therapy.
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IL-1β produced by pancreatic cancer cells suppresses immune attack on tumours
Researchers have discovered that pancreatic cancer cells secrete IL-1β to suppress the immune system and suggest antibody treatments as a therapy for pancreatic ductal adenocarcinoma.
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Study paves way for new vaccines to protect infants against infections
An mRNA vaccine has been developed which has elicited strong immune responses in mice in the presence of maternal antibodies.
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Application note: Custom Antibody Services
Since 1976, R&D Systems, a Bio-Techne brand, has developed and manufactured high-quality reagents for the bio-scientific industry.
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Antibody HIV therapy for primate newborns shows potential as therapy
A study has shown that administering two antibodies soon after birth can prevent HIV from developing in rhesus macaques.