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Combination of antibodies could improve cancer immunotherapies
A study has shown that using three antibodies with two different mechanisms of action could be a novel way to improve immuno-oncology treatments.
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Antibodies
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Antibody therapeutic candidate could be used to treat autoimmune diseases
Researchers have used a drug candidate to block a receptor that contributes to the development of autoimmune disease which could be a potential treatment.
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Significant breakthrough made in Zika virus vaccine development
Researchers have developed a novel T cell-based vaccine against the Zika virus that has proved effective in mouse models.
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Antibody characterisation – an essential researchers’ resource
Central to reproducibility in biomedical research is the ability to use well-characterised and defined reagents. The CPTAC Antibody Portal serves as a National Cancer Institute community resource that provides access to many standardised renewable affinity reagents to cancer-associated targets and accompanying characterisation data. Nikki Withers spoke to Dr Tara Hiltke…
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Application note: Custom Reagents & Contract Services
When your work demands unique reagents or scientific support, turn to the decades of product development legacy behind Bio-Techne’s trusted brands.
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Application note: CAR T Cell Research
Chimeric antigen receptor (CAR) T cell transfer has had success as a treatment for leukemia and lymphoma, but solid tumors have been more challenging due to the rarity of true tumor-specific target molecules and the immunosuppressive nature of the tumor microenvironment.
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Poster: Advantages of recombinant antibody engineering
Antibodies play a critical role in diagnostics and therapeutics. In these, and other applications, performance and consistency are critical.
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Vaccine strategy against chronic inflammatory diseases developed
A study in mice has shown that immunisation against bacterial flagellin could lead to protection from chronic inflammatory diseases.
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Expert view: The future of cell expansion for monoclonal antibody production
There is room for improvement in the production of monoclonal antibodies; commercial production needs increased process efficiency and reduced costs.
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Expert view – The Octet HTX system: enabling multi-purpose screening of therapeutic biologics during development
Current trends in the development of therapeutic biologics suggest that engineered molecules such as bispecific antibodies and antibody-drug conjugates are the future of the industry, yet despite this, monoclonal antibody (mAb) development remains a dominant focus.
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Antibodies could be used as nanotechnology builders
Endogenous human antibodies can be used to build and dismantle 2D and 3D DNA nanostructures, finds new research.
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Drug Target Review – Issue 4 2019
This issue includes a discussion on the future of high-throughput screening through collaboration, an analysis of mass spectrometry as a structural biology tool and an exploration of the challenges of hit-to-lead when researching tropical diseases. Also in the issue are articles on immuno-oncology and assays.
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Method to coax immune system into selecting HIV antibodies developed
Immunogens can be used to coax the immune system into producing broadly neutralising antibodies to fight a HIV infection, making a vaccine against the condition more likely, say researchers.
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Dengue vaccines may be improved by simulating amino acid starvation
Scientists have discovered that a plant-based compound called halofuginone activates a pathway that results in better antibodies and could improve the effectiveness of vaccines.
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Application note: A Simoa™ Bridging Assay for Anti Drug Antibody Detection
Therapeutic drugs based on biological materials (antibodies, hormones, cytokines, enzymes, fusion proteins) may have the ability to elicit an immune response in the host.