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Hidden influenza vulnerability found in human antibodies
Scientists have discovered an unexpected weakness in the influenza virus protein.
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Antibodies
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‘Inconsistent’ use of antibodies found in laboratory experiments
16 May 2019 | By
Researchers say they have affirmed inconsistencies in the use of a common laboratory procedure called immunohistochemical staining.
article
Squaring the circle – cancer vaccines
By the 1890s William B. Coley had injected streptococcal organisms in patients with solid tumours (“Coley’s Toxins”) to activate the immune system. Coley (1862-1936) was an American bone surgeon and pioneer of cancer immunotherapy. He was convinced that post-surgical infections had helped patients to recover better from their cancer by…
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Key step in the transformation of B-cells to antibody-secreting cells described
Scientists have detailed the role of a key controlling factor in the transformation of B-cells into antibody-secreting cells.
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Method for radiolabelling antibodies against breast cancer developed
Researchers from the University of Zurich have created a new method for radiolabelling antibodies using UV light - with proteins being ready-to-use for cancer imaging or therapy in less than 15 minutes.
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Human antibody discovery could save lives from fungal killer
Novel therapy uses antibodies cloned from patients who have recovered from an infection caused by the fungus Candida…
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Application note: A novel solution to expedite antibody discovery
With breakthroughs in molecular engineering and antibody humanisation, monoclonal antibodies (mAb) are one of the fastest-growing classes of biopharmaceuticals for multiple clinical indications including cancer, cardiovascular disease, autoimmune disorders and infectious disease. Most therapeutic antibody candidates are initially generated using hybridoma technology or primary B-cell screening after antigen immunisation.
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Charles River Laboratories continues commitment to oncology drug discovery
Team of oncology experts expand data in Tumor Model Compendium and present strong portfolio at industry conferences...
webinar
High throughput screening for deep mining of antibody repertoires, Dr. Stefan Moese, Novartis, Switzerland
9 November 2018 | By Beckman Coulter
In this webinar you learn about a high throughput screening approach for mining of antibody repertoires in the context of biologics drug discovery.
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Tethered antibodies may prevent influenza virus infections
Investigational therapeutic candidate made with four antibodies tethered together shows promise against influenza A and B...
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Charles River and Distributed Bio enter exclusive partnership to create an integrated antibody discovery and development platform
Charles River Laboratories International, Inc. announced that it has entered into an exclusive partnership with Distributed Bio, Inc., a leader in the computational design and optimisation of antibody discovery platforms...
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Antiphospholipid antibodies linked to heart attacks
Levels of antiphospholipid antibodies, which are associated with rheumatic diseases, are also elevated in myocardial infarction without any autoimmune co-morbidity...
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Better drug delivery through the blood-brain barrier
Drug delivery through the blood-brain barrier has shown to be difficult to overcome, but researchers may have discovered a method to overcome this issue...
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ELRIG UK Drug Discovery 2018 Event
ELRIG’s (European Laboratory Research & Innovation Group) Drug Discovery meeting, will take place at ExCeL, London, UK, located in the heart of the city, from 9 -10 October 2018...
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Expert view: Generate high‑content information using flow cytometry
Flow cytometry has become a widely used technology in life science research since its development in the 1970s. It is also essential for many biopharmaceutical and biotechnology companies due to its proficiency in identifying biomarkers, finding new inhibitory antibodies, and assessing the efficiency of new pharmacological protocols.