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Antibody targets create potential for a unified treatment approach
Antibody targets thought to cause the most damage in neurological disorders, creates potential for a unified treatment approach...
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Antibodies
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New imaging technique may predict the of spread breast cancer
Researchers have developed a radioactive ‘tracer’ molecule to detect myeloid-derived suppressor cells’ accumulating in the lung in preparation for the arrival of breast cancer cells...
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Novel immuno-oncology treatment for patients with advanced solid tumours
An experimental immuno-oncology treatment will move into early phase clinical trials for patients with advanced solid tumours...
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VRC01 antibody may prolong time to HIV viral rebound
A study has shown the infusion of a broadly neutralising antibody (VRC01) in virally suppressed volunteers associated with a modestly delayed rebound of HIV...
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Scientists discover how membrane necks get constricted and cut
Scientists at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) have succeeded in revealing a key mechanism of membrane deformation.
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AbCellera expands research collaboration with Teva
Collaboration extends initial partnership and aims to generate lead antibody candidates against membrane targets using AbCellera's antibody discovery platform…
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Numab and Kaken enter into an antibody collaboration
Numab Therapeutics announced a collaboration and option agreement with Kaken Pharmaceutical for the identification of a multispecific antibody candidate for development in inflammatory disease.
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Antibody is effective against radiation-induced pulmonary fibrosis
Radiation therapy is part of the treatment regimen for about two thirds of cancer patients today. Radiotherapy is well tolerated in most cases, but it can also lead to damage in healthy tissues that are also irradiated. One debilitating side effect is radiation-induced fibrosis. Fibrosis is a process of scarring…
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Antibodies as ‘messengers’ in the nervous system
Antibodies are able to activate human nerve cells within milliseconds and hence modify their function.
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Abeome and CDC to collaborate on Zika antibody discovery
The Zika virus, which is spread to people primarily through the bite of an infected Aedes species mosquito, is an impending threat to America’s borders, with over 5000 cases now reported in the continental US. Zika virus infection has been associated with Guillain-Barré Syndrome, and infection during pregnancy has been…
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GSK: A Lifetime in Fluorescence
GSK's top investigators explain why the data quality offered by Fluorescence lifetime detection technology for drug discovery applications is superior…
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Antibodies In-Depth Focus 2017
Lone Friis and David Matthews discuss developability assessment of therapeutic antibodies, and Negin Mokhtari and colleagues explain nanoparticle-mediated enzyme delivery for application in cancer therapy...
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Q&A: Lou Matis on bispecific antibodies
Drug Target Review Editor Steve Bremer talks to Pieris’ Chief Development Officer Lou Matis about bispecific antibodies.
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Drug Target Review – Issue #1 2017
Included in this issue: Importance of building patient trust; Vaccines & Immunology; Oncology; Assays; Biomarkers; and Antibodies...
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Developability assessment of therapeutic antibodies
Developability assessment is a broad term covering the evaluation of potential therapeutic candidates’ drug-like properties, manufacturability and safety profile. It is important to carry out this assessment as early as possible in the pre-clinical stage development to select the candidate with the most stable profile. This can minimise the risks…