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M6A modification is crucial for HIV-1 survival
The discovery of three m6A modifications and their exact locations could lead to the development of drugs that inhibit viral RNA and protein production.
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Antiretroviral Therapies
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The molecular mechanisms of lenacapavir revealed
Researchers discover a mechanism that could be exploited for targeting other viruses that build capsids to hide from host defences.
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Possible connection between HIV and tuberculosis revealed
A recent study has shown that antiretroviral therapy timing impacts the animal version of HIV and latent tuberculosis.
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Drugs that trigger immune system alarm could lead to new HIV therapies
Researchers have suggested that dormant HIV can be eradicated from cells by attacking it based on its viral activities.
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Novel CAR T-cell therapy could help cure HIV
The designers of the Dual Chimeric Antigen Receptor (CAR) T cell therapy report it slows HIV replication and leads to a smaller viral reservoir in HIV-infected mice.
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Discovering how drugs combat HIV and why resistance can occur
A group of researchers, led by Professor Zucai Suo, have revealed the mode of action of two HIV drugs and identified how resistance can develop, which they say could lead to improved drug design in the future.
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Antibody HIV therapy for primate newborns shows potential as therapy
A study has shown that administering two antibodies soon after birth can prevent HIV from developing in rhesus macaques.
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Progression, trends and industry leaders in HIV and AIDS research
HIV is a disease still common in sub-Saharan Africa despite global research since 1982. This article delves into the trends, opportunities and key players in HIV research, exploring future possibilities for treating the disease.
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Majority of HIV persistence during ART due to infected cell proliferation
Study confirms biological mechanism responsible for latent HIV reservoirs; suggests strategies for a functional HIV cure...
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IgG3 antibody can block B cells from fighting pathogens during HIV infection
Scientists have shown that in certain people living with HIV, a type of antibody called immunoglobulin G3 stops the immune system's B cells from doing their normal job of fighting pathogens...
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Computer simulations predict the spread of HIV
Genetic signatures trace the origin of infection and its potential path through populations, allowing state health departments to track the disease...
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IgM antibodies protect against HIV-1 infection
A group of scientists have zeroed in on a new defence against HIV-1, the virus that causes AIDS...
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SPECT Imaging technique illuminates immune status of monkeys with HIV-like virus
Approach could improve understanding of immune system recovery in people treated for HIV infection...
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HIV vaccine elicits antibodies in animals that neutralise dozens of HIV strains
NIH study results represent a major advance for structure-based HIV vaccine design...
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CRISPR used to destroy the regulatory genes of HIV
By destroying the regulatory genes of the AIDS virus HIV-1 using the genome editing system CRISPR/Cas9, researchers have succeeded in blocking the production of HIV-1 by infected cells...