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Biologics

Drug Target Review Upstream Bioprocessing ebook 2021

13 December 2021 | By Drug Target Review

In this ebook, find an article on 3D tissue cultures from biopsy samples to evaluate the preservation of tissue-typical protein expressions as well as a piece on a new process analytical technology (PAT) system to assess N-glycosylation during upstream cell culture bioprocessing.

article

Drug Target Review – Issue 4 2021

13 December 2021 | By Drug Target Review

This issue includes articles that discuss the development of long-term 3D tissue cultures from human biopsy samples, the application of flow cytometry in drug discovery and automation for upstream processing in a biologics manufacturing environment. Also included are features on informatics, proteomics and CRISPR.

podcasts

Episode 3 – Cell & gene therapy with Dr Sam Wadsworth, Ultragenyx Pharmaceutical & Dr Eric Ostertag, Poseida Therapeutics

1 November 2021 | By Drug Target Review

Tune in to this podcast to learn about AAV vectors for gene therapy delivery and engineering CAR T cells against solid tumours.

video

Engineering better CAR T cells with Professor Ann Ager, Cardiff University

27 October 2021 | By Drug Target Review

Watch this exclusive interview with Professor Ann Ager, Cardiff University, to discover how CAR T cells could be targeted against solid tumours.

video

Discussing next-gen AAV vectors with Dr Arun Srivastava, University of Florida

30 September 2021 | By Drug Target Review

An interview with Dr Arun Srivastava about his research into safe and effective AAV vectors that do not prompt a reaction from the immune system.

whitepaper

Cell & Gene Therapy Advancements Whitepaper

16 September 2021 | By Drug Target Review

Download this whitepaper to discover the latest research and developments in cell and gene therapies via exclusive articles and interviews.

news

New biomarkers may help prevent diabetes-related blindness

17 August 2021 | By Anna Begley (Drug Target Review)

US researchers have identified new biomarkers that can detect early changes in the eye that can lead to diabetes-related blindness.

news

Record-breaking 3D bioprinter could speed up drug development

16 August 2021 | By Anna Begley (Drug Target Review)

Nanoengineers have developed a high-throughput bioprinter that 3D prints at record speed, potentially accelerating drug development.

news

Synthetic antibody treats congenital myasthenia in mice

28 June 2021 | By Victoria Rees (Drug Target Review)

Researchers have designed an antibody that attaches to MuSK, which prevented early lethality of mice with congenital myasthenia.

news

New technique developed for identifying therapeutic nanobodies

25 June 2021 | By Victoria Rees (Drug Target Review)

Researchers have used a new method for discovering nanobodies to identify potential therapeutics against SARS-CoV-2 infection.

whitepaper

Product hub: Octet^® R series systems

24 June 2021 | By Sartorius AG

Discover the new Octet R series systems, a comprehensive solution for screening and characterising molecular interactions such as protein-protein or protein-drug interactions.

article

Using cholangiocyte organoids to regenerate human bile ducts

22 June 2021 | By Dr Fotios Sampaziotis (University of Cambridge)

A team of researchers has shown that injection of cholangiocyte organoids in human livers ex vivo can repair the organs’ bile ducts. In this article, Dr Fotios Sampaziotis explains how his team’s study provides the first proof-of-principle for the efficacy of cellular therapies using organoids in human.

article

Better therapeutic antibodies by design

21 June 2021 | By Aparajita Dubey (CRAMbridge)

The binding specificity and high binding affinity of therapeutic antibodies makes them an ideal therapy for treating a wide range of human disorders. Advancements in antibody technologies have resulted in huge development success along with a boost in novel and improved treatment strategies. However, specific challenges and considerations are faced…

article

How to mix the best anti-SARS-CoV-2 cocktail

21 June 2021 | By Dr Zhiqiang Ku (University of Texas Health Science Center at Houston)

Neutralisation resistance generated by Spike (S) protein mutations in Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) poses a challenge to antibody therapies for COVID-19. Antibody cocktails targeting the S protein receptor binding domain (RBD) are one way to avoid viral neutralisation escape, however only certain antibody combinations are currently effective.…

article

Drug Target Review Antibodies ebook 2021

17 June 2021 | By Drug Target Review

Within this ebook, find articles on antibodies to combat SARS-CoV-2 and an evaluation of the various therapeutic forms they can take.

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Biologics