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HIV infant model opens new avenues for research
An animal model to test HIV infection in infants could lead to biomarkers that predict viral rebound after ART interruption.
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Biomarkers
Biomarkers are a naturally occurring molecule, gene, or characteristic by which a particular disease can be identified.
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Motor neuron disease electrical signalling pathways mapped
A study has used EEG to investigate the neuron networks that act abnormally in the condition, providing a significant step in the search for treatments.
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Study identifies potential drug target for prostate cancer
Researchers have discovered a non-coding RNA which could be used as a biomarker and in new therapies for prostate cancer.
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Case study: Shipping media for fresh tissue
For biomarker discovery efforts, primary cell assays, and patient-derived xenograft work, among others, access to fresh human surgical tissue is an essential component in obtaining reliable results.
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Neuromelanin-sensitive MRI could measure biomarker for psychosis
A specific type of MRI, neuromelanin-sensitive magnetic resonance imaging, could lead to the measurement of a psychosis biomarker...
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Developing a blood test for pain measurement
A blood test to measure pain has been developed, and could potentially aid physicians with more accuracy in diagnosis and prescriptions...
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Diagnostic technique reveals biomarker differentiating bladder cancer from inflammation
A biomarker that can differentiate between chronic cystitis (inflammation of the bladder) and a non-muscle invasive-type blood cancer could aid diagnosis...
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Protecting vision after optic nerve trauma using arginase 2
Arginase 2 could be used as a drug target target to protect vision after optic nerve trauma, as removal of this enzyme decreases retinal neuron death...
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Tongue microbiome could help to detect early-stage pancreatic cancer
The bacteria living in the tongue's microbiome could provide an insight into an individuals heath, and may help to detect pancreatic cancer earlier...
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Ubiquilin-4 biomarker links cancer progression to genome instability
High level of specific protein in tumours indicates prognosis as well as optimal treatments...
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Editing enzyme could promote tumour suppressor loss
The detection of 'copy editing' by a stem cell enzyme in over 20 tumour types could be a biomarker and possible therapeutic target for certain cancers...
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Expert view: High-throughput screening – make an impact by removing barriers
For drug discovery and biomarker research, screening campaigns are employed to identify potential new treatments for diseases and to answer questions that remain unknown in the scientific community.
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Under the microscope: CROs and microplate reader requirements
Contract Research Organisations rely on microplate readers for effective hit discovery. Ian Waddell, of Charles River Laboratories, explains what his needs are.
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Biomarkers may predict Zika-related birth defects
Researchers have identified biomarkers associated with severe birth defects in babies born to women infected with the Zika virus...
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Biomarker discovered for heart failure with preserved ejection fraction
A biomarker has been discovered for the most common type of heart failure - heart failure with preserved ejection fraction...