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Biomarkers

 

Biomarkers are a naturally occurring molecule, gene, or characteristic by which a particular disease can be identified.

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Synthetic macrocyclic receptors as tools in drug delivery and drug discovery

10 October 2014 | By ,

Macrocyclic compounds (see Figure 1) have fascinated medicinal chemists for generations. The first ones which have been characterised are the naturally occurring cyclodextrins (CDs), cyclic oligomers of glucose, which can be obtained by bacterial synthesis from starch. Calixarenes (CXs) were among the first man-made macrocycles, followed by crown ethers (Pedersen,…

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AstraZeneca advances tralokinumab to Phase III in severe asthma

14 August 2014 | By AstraZeneca

AstraZeneca announced the start of the Phase III programme for tralokinumab, a potential treatment for patients with severe, inadequately controlled asthma, developed by MedImmune, the company’s global biologics research and development arm...

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Drug Target Review – Issue #1 2014

9 May 2014 | By Guido Rasi, Professor Sir Mark Pepys, Kenji Schorpp et al.

We are delighted to welcome you to the inaugural issue of European Drug Target Review, a magazine focused on the changing landscape of the drug discovery industry...

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Academia Big Pharma collaboration in drug development

5 May 2014 | By

Clearly what is needed is a synergistic collaboration bringing together the respective competence and expertise of academia and industry. All the major pharmaceutical companies have recognised this need and have introduced a range of different models for association with academia and small biotech or biopharma companies. Attempted solutions range from…

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Oncology biomarkers in clinical practice – a new horizon

4 May 2014 | By , ,

The ability to individualise a patient’s care has become a particularly pressing issue in the field of cancer therapeutics as there is a growing recognition that both the global incidence of cancer is steadily rising and the associated costs in terms of treatment and lost productivity are ever increasing. Advances…